0Shares

The History Of 'Virology' Fraud From Smallpox to SARS

A very long post/page but I would invite you to consider this encapsulation of scientific history, mostly via videos that has resulted in nearly all diagnoses and nearly all drugs produced to ‘treat’ the ‘symptoms’ that are backed by no empiric evidence; ‘a house of cards’. While some minor ‘opinions’ might not be established regarding various toxins/pollutants/endemics the ‘principles’; meaning the fraud of ‘virology’ is firmly established. I will keep adding to this post if I see more educational videos.

Anti ‘Viral’ Track Record

Pfizer’s Covid pill regiment – Paxlovid – consists of a mix of two drugs – one being nirmatrelvir, which is meant to stop the SARS-CoV-2 virus from replicating, and the second, ritonavir, is an agent that acts to prolong the duration of the first.

Anti viral hospital track record:

-“Trends in hospital deaths among human immunodeficiency virus
patients during the antiretroviral therapy era, 1995 to 2011” -Journal of
Hospital Medicine Volume 10, Issue 9, pages 608–614, September 2015-
(“CONCLUSIONS: Non-AIDS deaths increased significantly during the ART era and are now the most common cause of in-hospital deaths”)

In 1991 Anthony Fauci proved that the “HIV” phenomena could be inhibited by antioxidants.
(Kalebic T, Kinter A, Poli G, Anderson ME, Meister A, Fauci AS. Suppression of human immunodeficieny virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine. Proc. Natl. Acad. Sci. U S A 1991;88:986-990).
 

Why did Anthony Fauci, his cohorts, colleagues and others continue to fund and/or research harmful injections and drugs when he/they knew that every ‘virus’ aka non living cellular debris’ could be rendered harmless or become more deadly with the addition of various intoxicants?

This ‘dead’ material/cellular debris would normally be phaged or autophaged (digested) in a normal person by macrophage activation and/or removal of the intoxicants to prevent a cytotoxic/cytopathic effect and cascade.  Macrophage activation is harmless and a normal part of cellular repair and renewal. 

Virology is re-producible fraud.

This includes any and all tests that require any protein/fragment (PCR RT-PCR or nucleotide/s and includes ELISA/Western Blot and many others that measure oxidative stress and/or markers determined by predictive immune response.

In other words, producing the desired effect (with an intoxicant or method) and then measuring that known effect and/or marketing that effect by coining that effect ‘a disease’ to engage in ‘treatment’ is medical fraud. If that treatment arising from that fraud generates income, it’s felony fraud and conspiracy to commit felony fraud (RICO).

This type of medical fraud is not protected from any liability shield.

If that natural effect is amplified to produce harm greater than that which occurs in nature it is defined as a biological weapon. 

Decades of scientific revolt against the fraud of ‘virology’.

The First ‘Barrington Declaration’ occurred shortly after HIV was announced as an epidemic which led to ‘mandatory’ HIV testing that caught thousands in an HIV dragnet, similar to what is occurring today. Eventually this pre marital mandatory testing was dropped but not before producing serious harmful outcomes.

Thousands of scientists spoke out and signed a document declaring HIV a criminal fraud. Below is the historical record.

The CDC, NIH, NIAID, FDA, AMA, UN, WHO and all other Govt. agencies, regulatory bodies and religious institutions in the world fund or promote health fraud and felony.

CDC No Longer Recognizes the PCR Test As a Valid Method for Detecting “Confirmed Covid-19 Cases”
As of  January 1, 2022, the CDC in a request to the FDA withdraws it’s endorsement of the RT-PCR test.  
 
The CDC acknowledges that the PCR test does not effectively differentiate between Covid-19 and Seasonal Influenza. 
 
Amply documented and analyzed by numerous scientists, the RT-PCR test does not detect or identify SARS-CoV-2 and its variants.

 

Reduction of ‘viral load’ is antibody independent.

Zero Risk Flu Or SARS With A Healthy Microbiome – Here’s Why…

 

*This is based on natural science theory, which is that ‘flu’ is actually a detox event or dysfunctional ‘phage’ or ‘autophagic’ event.

Phagocytosis, Autophagy – Normal bodily process producing clearance of ALL cellular debris.

Checkpoint Blockade Toxicity (Cancer drugs, mab drugs, other injections) – Induced Auto Inflammatory Effects, increasing damage to organs and risk of malignancy.

Autophagy Inhibition, Autophagy Inhibitor Drugs – Induced immune suppression. Dr. Robert Malone (inventor MRNA) is still working to produce and re-purpose drugs that are termed ‘autophagy inhibitor’ drugs. His entire career has been spent on this type of drug development despite knowing that these drugs are taken up by embryos and could produce severe birth defects as well spontaneous abortions. 

For other drugs contraindicated in natural oral immune therapy visit… 

 
Stepwise treatment of purified serum Gc protein with immobilized B-galactosidase and sialidase generates probably the most potent MAF (macrophage activating factor) (termed GcMAF) ever discoverd that produces no side effect in humans. 

Dr. Nobuto Yamamoto Associate professor at Gifu Medical School, Japan until 1959. Visiting scientist in the Microbiology Group at the Institute for Cancer Research (Fox Cancer Center), Philadelphia, PA, from 1959 to 1961; studied the genetic evolution of bacterial viruses. Faculty at Temple University, Philadelphia, PA, as Head of Virology and Genetics of the Fels Cancer Research Institute where he served until 1980. Appointed professor of Microbiology and Immunology at Hahnemann University School of Medicine, where he continued to study viral evolution and revived his graduate study of immunology from 35 years before. His immunological studies emphasized mechanism of macrophage activation and discovered GcMAF. When Dr. Yamamoto retired from Hahnemann University in 1990, he returned to Temple University Medical School as a Research Professor of Biochemistry. There he studied the tumoricidal capacity of macrophages activated by GcMAF and cancer therapy with GcMAF. In 1994 Dr. Yamamoto became the founder and director of the Socrates Institute for Therapeutic Immunology.

The 2016 Nobel Prize in Physiology or Medicine has been awarded to Yoshinori Ohsumi for his discoveries of mechanisms for autophagy — a fundamental process for degrading and recycling cellular components.

Thanks to Ohsumi and others following in his footsteps, we now know that autophagy controls important physiological functions where cellular components need to be degraded and recycled. Autophagy can rapidly provide fuel for energy and building blocks for renewal of cellular components, and is therefore essential for the cellular response to starvation and other types of stress. Autophagy can eliminate intracellular debris. Autophagy contributes to embryo development and cell differentiation. Cells also use autophagy to eliminate damaged proteins and organelles, a quality control mechanism that is critical for counteracting the negative consequences of aging.

Disrupted autophagy has been linked to Parkinson’s disease, type 2 diabetes and other disorders that appear in the elderly.

Health Winning Science

A dysfunctional autophagic mechanism leads to chronic intestinal inflammation in IBD. IBD is not just leaky gut

* Intestinal barrier loss alone is insufficient to initiate disease (IBD).

Currently available treatments which target the systemic immune system, induce immunosuppression, thereby exposing the patient to the risk of infections and malignancy. The interplay between the gut and the systemic immune system determines the final effect on target organs, including the bowel mucosa. ….. an altered systemic immune response leads to inflammation-mediated damage to the gut and other organs.

Clinical & Translational Immunology (2016)

The WHO recommends that immunization or treatment be orally administered. (1998, 2006, 2011)

Any ‘inoculation’ is an attempt to induce ‘tolerance’ to greater and greater levels of toxins or allergens; fundamental error as all injections produce the same toxic effects. 

About MRNA Injections (all)

Known adverse events and damage which can not be reversed due to genetic editing mechanisms of action:

  • blood cell changes – clotting or bleeding
  • immune system exhaustion (AIDS)
  • production foreign proteins????
  • neurological damage
  • multiplication of cells beyond the ability to self regulate or repair – chromosome damage/aneuploidy/cancer
  • uncontrolled inflammatory response syndromes
  • genetic damage
  • infertility
  • heart damage
  • multiple organ damage

 

Virology On Trial Series

3-18-22

I don’t know how many parts are actually in this series, I don’t know who made the original or if it is continuing but I will add them as they pop up in my feed.

HIV=AIDS – FAUCI’S FIRST FRAUD

 

DR TOM COWAN ABOUT THE INVISIBLE VIRUS

 

THE CONTAGION MYTH

VIRAL CULTURES

What Do “Virologists” Have To Say Regarding The Isolation Of “Viruses” From Samples Taken Directly From A Patient

If you read Immune For Life you would clearly understand that all cellular debris classified as waste and that they pre ‘determine’ ’cause’ ‘disease’ are actually conditions which the body is quite capable of addressing and eliminating in all bodily systems including the spine, the brain and the blood with a few easily obtained substances.

 

The Third And Final Pillar Of Virology – The Genome

DESTROYS THE ENTIRE MAINSTREAM MEDICAL CONCEPT OF CONTAGIOUS VIRUSES AND COVID19

A direct correlation with 5G is not determined. As a single factor intoxicant graphene oxide can cause the exact symptoms via lung damage.

‘THE EMPEROR’S NEW CELL CULTURE’

Dr. Kaufman Replies To Jeremy Hammonds On The Isolation Of Viruses

 

DR KAUFMAN VS DR WODARG DEBATE ON FUELLMICH’S CORONA COMMITTEE & DR COWAN COMMENT

 

DR. THOMAS COWAN – DO THE PICTURES ON THE ELECTRON MICROSCOPE PROVE THAT SARS-COV-2 EXISTS?

 

LAB CREATED VIRUSES: SMOKING GUNS OR BAD SCIENCE?

Eviscerating Moderna patent.

GAIN OF FUNCTION GASLIGHTING – DR. SAM BAILEY

 

Dr. Thomas Cowan, MD: Normal Immune Function & Vaccination Interference

Deadly Deception

Pay close attention to what he says about malnutrition and radiation.

THE VIRUS-THEORY HOAX HAS CREATED A TRILLION DOLLAR FRAUD INDUSTRY

UNMASKING THE PROOF OF FLU TRANSMISSION

DR. COWAN: THE DEATHVAXXINATION PROGRAM IS INCREASING HIV AND CANCER RATES

Salk Was A Fraud – Polio

Anti Poliomyelitis activity of human and bovine colostrum and milk. SABIN AB, FIELDSTEEL AH. Pediatrics. 1962 Jan;29:105-15.
Antipoliomyelitic activity of human and bovine colostrum and milk. SABIN AB, FIELDSTEEL AH. Pediatrics. 1962 Jan;29:105-15.

Polio reduction statistical ‘proof’ of ‘vaccine efficacy’ was produced in much the same way as measles as seen in the above video Vaccine Interference by Dr. Tom Cowan. Some of the ‘toxic’ areas visited to ‘investigate’ Polio outbreaks were Cleveland, Cincinnati and Pittsburgh, within the next decade or so some of these rivers became so polluted they caught fire.

This was a typical ‘ploy’ of the ‘investigative agencies’ who later declared an ‘organism’ to be the culprit rather than investigate a ‘pollutant’ – from Lyme to CFS. 

COMPREHENDING THIS CHANGES THE ENTIRE NARRATIVE!!! Θ IT’S TIME FOR EVERYONE TO KNOW!!! (FULL VIDEO)

I present this historical overview with discretion. While ‘radiation and EMF frequency’ produces definite harmful effects, the effects of 5G are not known at this time. I’ll continue to monitor the effects of 5G as the evidence becomes available. This includes the combined effect of 5G and graphene oxide.

Smallpox

Feline IBD – Treating Your Animal For IBD

Just a few dangers regarding bio sludge.

Organically acquired symptoms:
Sudden loss of taste or smell and fast onset bilateral pneumonia is the result of an intoxicant, possibly inhaled, possibly absorbed, possibly injected. Possibly a gas or chemical reaction or combustion. Possibly an aerosol, possibly an airborne pollutant (dust, mold spores, filaments, metals, shavings etc.) Possibly a radioactive effect. It always was.
See library.
For deadly H2S and toxic byproduct symptoms including those that can be the result of ‘bio sludge’ which is a bio hazard.

Drug Pollution

Just The Tip Of The Iceberg – More Bad News About Vitamin D How easy it is to poison yourself with synthetics.

Vitamin D is a hormone precursor.
I only recommend cod liver oil, regular whole fat mammal milk with naturally occurring amounts of Vitamin D and other natural sources, including daily sunlight.
It doesn’t take high amounts of Vitamin D to be effective, even on cloudy days. This gauge of effectiveness can easily be found in large study groups directly comparing cod liver oil with synthetic D3 for health benefit. You can also learn that seasonal decline, malnutrition or detoxification events (meaning hair loss, skin issues, rashes, arthritic conditions, poor carb digestion issues etc.) do not occur in animals in early nutrition studies that extend beyond 365 days; meaning there is no association between less sunlight/season and autoimmune diseases. There is such a thing as Vitamin D resistance and without oleic acid and sulfate for accelerated clearance it can bio accumulate and become toxic. With those substances it can be a highly effective macrophage activating factor transport mechanism for GC Protein or VDBP (Vitamin D Binding Protein). The addition of sugar to fish oils can also lead to rancidity so the benefits of fish oil or any healthy oil can quickly become a non benefit with the addition of some sugars. Early malnutrition studies that relied on butter quickly determined this. If you want to see how easy it is to mis-use Vitamin D you can visit the library to see how D metabolites were researched as use for birth control methods. Most would be surprised to learn that D3 is a rodent poison. High dose D3 in those who aren’t proficient in metabolizing is the equivalent to rodent poisoning in humans. Early malnutrition studies did not use synthetic D vitamins but relied on natural sources and milk was initially fortified with cod liver oil. I know of severe lesion formation with D3 intoxication. I also know of extremely high levels of D2 (ergosterol) in those who did not supplement with either synthetic form of D. With some synthetic vitamins the effects aren’t so bad as they are easily excreted, not so with synthetic D’s or Vitamin A. Some have little problems with synthetic D3 or D2, some have severe problems, I say why take the chance when there are virtually no problems from natural sources and there is only benefit. The only synthetic vitamins I recommend as needed are sodium ascorbate (C) and pantothenic acid. Sodium ascorbate and whole fat mammal milk is an excellent and fast detoxifier of nearly all toxins with no need to determine the specific toxin. No synthetic vitamin is equal to how they are made and synthesized from friendly organisms via a healthy gut.
I suspect most forms of D fortification in cereals began with the effort to prevent product loss from rodents and this fortification was quickly branded as a health benefit. Later it was observed that the rodents lived longer consuming the box rather than the cereal. Whole fat mammal milk today only contains naturally occurring amounts of the vitamin.

Merck

Cholecalciferol (vitamin D3) is used both as a dietary supplement and a rodenticide. It appears to be toxic at a much lower dose when consumed in a bait form than when ingested as a technical grade agent. Most rodenticide baits contain 0.075% cholecalciferol. Incidence of vitamin D3 toxicosis in animals is relatively less than that of anticoagulant and bromethalin toxicosis. Relay toxicosis from vitamin D3 has not been documented. One international unit (1 IU) of vitamin D3 in nutritional supplement is equivalent to 0.025 mcg of cholecalciferol.

Cholecalciferol toxicosis is characterized by hyperphosphatemia and hypercalcemia, leading to renal failure, cardiac abnormalities, hypertension, CNS depression, anorexia, vomiting, diarrhea, and lethargy. The increased calcium and phosphorus can lead to calcification of soft tissue, notably the highly vascular areas of kidneys and lungs, as well as within the walls of the great blood vessels.

Clinical signs generally develop within 18–36 hr of ingestion; initial signs can include depression, anorexia, polyuria, and polydipsia. The serum phosphorus more commonly rises first, at ~12–24 hr after ingestion, with serum calcium levels rising within another 12–24 hr. Nausea, vomiting, hematemesis, and depression are common as the clinical signs progress. It is important to obtain a baseline biochemistry profile as early as possible after the exposure, so that each animal can be monitored based on individual values.

Ingestion of vitamin D3 at >0.1 mg/kg may require decontamination (induction of emesis and administration of activated charcoal) and monitoring of serum calcium, phosphorus, and renal values. Emesis can be induced within 2 hr of exposure with 3% hydrogen peroxide or apomorphine in dogs and xylazine in cats. Activated charcoal at 1–2 g/kg is an appropriate initial dose for decontamination, and a second half dose after ~6–8 hr may be helpful. In addition, use of cholestyramine, a bile acid sequestrant, may be useful to decrease the body burden of vitamin D3 that undergoes enterohepatic recirculation with bile acids. However, the efficacy of cholestyramine to reduce vitamin D3 levels in dogs has not been determined. The recommended dosage is 0.3–0.5 g/kg, dissolved in liquid and administered orally every 6–8 hr for 3–5 days, depending on the initial dose of cholecalciferol ingested. Premature initiation of calciuresis (see below) may disrupt normal calcium-phosphorus metabolism, triggering osteoclasts to move additional calcium into the blood stream, artificially increasing serum calcium and phosphorus levels and mimicking vitamin D3 toxicosis.

Once the biochemical values begin to increase, there are two approaches to management. The first is to promote calciuresis by administering normal (0.9%) saline at 2–3 times normal rates. Furosemide at 2.5–4.5 mg/kg, PO, every 6–8 hr promotes calcium excretion but can also increase fluid loss (so hydration status should be monitored). Prednisolone at 1–3 mg/kg, PO, bid-tid, can reduce bone resorption as well as decrease calcium absorption from the intestine. Treatment with a phosphate binder (aluminum hydroxide 30–90 mg/kg, PO, in divided doses) to decrease phosphorus absorption and feeding a diet low in calcium should also be considered.

The preferred treatment for persistent significant hypercalcemia is pamidronate, an injectable bisphosphonate that inhibits osteoclastic bone resorption. It is administered at 1.3–2 mg/kg via slow IV infusion in saline over 2 hr. After administration, as the calcium and phosphorus levels start to decrease, supportive therapies (furosemide, prednisolone) should be tapered. A repeat dose may be required if significant hypercalcemia redevelops.

In the past, use of salmon calcitonin (administered at 4–6 IU/kg, SC, every 2–3 hr) has been suggested to decrease calcium and phosphorus levels, but this treatment is no longer used commonly. The two major disadvantages are that some animals may become refractory to calcitonin, and that once this therapy is instituted the use of pamidronate is not helpful.

Calcium and phosphorus levels should be monitored and treated until they return to baseline. Treatment may have to be continued for days or weeks because of the lipophilic nature of vitamin D3. Renal function should be monitored, and other clinical signs treated as needed.

The Pandemic Of Not Thinking

The undercurrents of corruption.

Dr. Sam Bailey interviews Dr. Tom Cowan. A great interview. Regular whole fat pasteurized mammal milk claims are extremist. Telling an African to prevent AIDS and/or malnutrition without milk never happened unless this was a group of Africans that was optimally breastfed, they’d be just as sick as you if not more due to factors 2 and 3, regardless of ANY post toddler diet. Probably over 50% of research regarding natural oral immune therapy, gut immune health and 90% of WHO Millennium Goals came about from studying malnutrition syndromes and AIDS in Africa so….. simply not true as no diet could rescue them from Kwashiorkor without milk and a couple of other substances. I would never put it out there that someone can’t achieve health without having these ‘exclusive’ items that are out reach for most because it simply is not true. If they read WHO Millennium statement or many other current studies, they’d be much further ahead. Organic and UHT milk are in their own category regarding denatured proteins due to high heat processing. Pasteurizing is not high heat and regular whole fat mammal milk retains its nutritional value. Of course kefir is better as the first way milk was preserved but that isn’t going to happen on a commercial level to the extent it does with grains but to claim no benefit when you can re-create the entire spectrum of health benefits with minimum effort is a misrepresentation of facts. I didn’t use kefir grains until long after I was completely healed and I am the definition of SAM (lifelong gut/immune health issues). I used LifeWay kefir, probiotics, yogurt, regular whole fat milk and colostrum daily for two years (and of course I continue) and that was it aside from my short stint in the beginning with an maf product and SIBO recipe. I later went on to refine the approach to be more gentle, minus the then commonly used maf production method using a yogurt maker.  I reviewed a good kefir grain product when I finally found one that is similar to European Kefir regarding the greater number of organisms than can be found in commercial store bought kefir for those who would like to try it but I would never claim that an ‘exclusive’ product or approach is required. Even the experts in oral natural immune therapy don’t claim that.

THE MAGICIANS TWIN C.S. LEWIS AND THE CASE AGAINST SCIENTISM

FR. Nolan: Politicians Have Killed The Innocent & Covered It Up In The Past

What to say and walk away….

What you say and then walk away.

How to not let anyone mischaracterize anything. Say zero risk of ‘flu’ or ‘SARS’ with a healthy microbiome and perhaps they should examine what ‘toxins’ they might be exposed to that are making giving them a particular condition (or that they may be experiencing an ‘intoxication’ or ‘detoxification’ event). This will shut even a so called ‘expert’ up as they will have no defense to counteract zero risk factor and will have to address the ‘toxic’ factor only. Without the toxin there is no effect. And then you say to date only injections are known to cause this cytopathic non controlled auto inflammatory effect via systemic targeting that you are promoting as ‘CV19’ unless you have some other known intoxicant that you might be aware of that is causing loss of taste or smell, diarrhea or fast onset bilateral pneumonia (those are the only known onset symptoms that have been described in the literature, fever is not included). 

If they can’t muster an intelligent response, walk away.

Words have meaning….

There is a particular reason why medicine and law and other documents are ‘scribed’ in latin and that reason is so that ‘definitions’ can not evolve and become slang terminology therefore a distortion or corruption of meaning. This prevents harm and injustice.

 

The word virus in latin means venom, poison, toxin. A submicroscopic agent that is unable to grow or reproduce. Classified as non living matter, non living things have no potential, that means development or possibility, therefore only susceptible to degradation.
 
On the term pharmakeia–an abstract noun meaning sorcery, magic, the practice of magic arts. Enchantment is the proper translation.
 
The concrete noun is pharmakon whose primary meaning is poison; its secondary meaning is magic potion or charm to achieve a desirable objective; and its tertiary meaning is medicine, remedy, or drug for healing. (Pharmacy) 

More info

You can learn more info in about section regarding common gut/immune disorders, gcmaf and the library for research sources. Immune For Life is your complete guide to gut and immune health including how to make maf products, gentle formulas, recipes and more. Timeless gut/immune health and nutrition info that will protect you, no matter your age, your family and future generations.

Alternavita: All you need to know (critical info in a nutshell)..... by focusing exclusively on these foundational health and immune development issues up to 90% of chronic conditions can be eliminated.

WHO STATEMENTS: 2017 Millennium Goal

  1. Breastfeeding,
  2. food (security)
  3. and water security (sanitation)

are major protective factors against malnutrition and critical factors in the maturation of healthy gut microbiota, characterized by a transient bifidobacterial bloom before a global rise in anaerobes. Early depletion in gut Bifidobacterium longum, a typical maternal probiotic, known to inhibit pathogens, represents the first step in gut microbiota alteration associated with severe acute malnutrition (SAM). Later, the absence of the Healthy Mature Anaerobic Gut Microbiota (HMAGM) leads to deficient energy harvest, vitamin biosynthesis and immune protection, and is associated with diarrhea, malabsorption and systemic invasion by microbial pathogens. A therapeutic diet and infection treatment may be unable to restore bifidobacteria and HMAGM.

 

Researchers found that malnourished children’s microbiota failed to follow the healthy pattern they identified in healthy children. The microbiota of malnourished children is immature, lagging in development behind that of their healthy peers. Supplementing these children’s meals with widely used therapeutic foods that increase calories and nutrient density reduces deaths from malnutrition, but it does not fix their persistent microbiota immaturity.

“Perhaps more insidious than slowing growth is malnutrition’s effect on less visible aspects of health, including impaired brain development and dysfunctional immunity, which follow these children throughout their lives”.

The Father of The Microbiome

Dr. Jeffrey Gordon

SIBO

SIBO can cause severe malabsorption, serious malnutrition and immune deficiency syndromes in children (non breastfed) and adults. 

Prognosis is usually serious, determined mostly by the underlying disease that led to SIBO.

 

Immunizations

The WHO recommends that immunization or treatment be orally administered due to economic, logistical and security reasons. Furthermore, this route offers important advantages over systemic administration, such as reducing side effects, as the molecules are administered locally and have the ability to stimulate the GALT immune responses  (Levine and Dougan, 1998Neutra and Kozlowski, 2006Bermúdez-Humarán et al., 2011).

 

Infections

For ANY infectious or parasitic disease to start, it is ALWAYS a requisite that the host suffer IMMUNODEFICIENCY. At the same time, infectious and parasitic diseases themselves cause additional IMMUNE SUPPRESSION and more MALNUTRITION. This immune suppression is SECONDARY to the accumulation of free radicals, especially oxidizing species, that occurs during and after infectious and parasitic diseases.

Clinical Aspects of Immunology and Biochem J.

 

Current IBD Research 2016

Currently available treatments for IBD, which target the systemic immune system, induce immunosuppression, thereby exposing the patient to the risk of infections and malignancy. The interplay between the gut and the systemic immune system determines the final effect on target organs, including the bowel mucosa. Inflammatory bowel diseases (IBD) are associated with an altered systemic immune response leading to inflammation-mediated damage to the gut and other organs.

Clinical & Translational Immunology (2016)
Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel

Most importantly, the immune modulatory agents used today for IBD do not achieve remission in many patients.

Not all IBD patients benefit from currently available drugs. Young people with IBD do not want to be on long-term drug therapy. Oral immune therapy, while not yet studied in large cohorts of patients, may provide an answer to this unmet need.

Clinical & Translational Immunology (2016)
Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel

Tolerance

Tolerance is the ability of the immune system to ‘see’ and respond appropriately. Without galactose (a necessary sugar) the immune system can not 'see'. Your immune system would not be able to function without galactose Your body wouldn’t know which cells are “good” and what cells are “bad.” Your body wouldn’t know who the invaders were and which ones should be attacked by antibodies. As you will learn the importance of these ‘sugars’ in gut microbiota health is a rapidly expanding field of research, only recently discovered, including HMO's (human milk oligosaccharides).

Why galactose? Milk sugar aka lactose has been shown to be very beneficial for the human body though unlike sucrose, lactose is made up of glucose and galactose. There is no fructose in lactose. It is a healthy disaccharide sugar. Galactose is known as the “brain sugar” and supports brain development of babies and children. Galactose helps triggers long-term memory formation. Galactose has been shown to inhibit tumor growth and stop its spread, particularly to the liver. This beneficial sugar can also enhance wound healing, decrease inflammation, enhances cellular communication, and increases calcium absorption.
What does immune ‘tolerance’ mean in simple language?
Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to substances or tissue that have the capacity to elicit an immune response in a given organism. The Th1 cytokine profile is vital for clearance of certain organisms and ancillary immune activity, and a limiting effect on this cytokine profile may result in reduced chances for overcoming infections especially intra-cellular organisms residing within macrophages. Effective clearance will depend on appropriate macrophage activation (which occurs through IFN≥ release by Th1 and NK cells) and production of nitric oxide. If this pathway is disrupted IFN≥ secretion is blocked, impairing macrophage activation. Persistent blockade of these inhibitory receptors has lead to the breakdown in immune self tolerance, thereby increasing susceptibility to autoimmune or auto-inflammatory side effects, including rash, colitis, hepatitis and endocrinopathies. Many drugs may cause checkpoint blockade toxicity including pharmaceutical drugs termed ‘immuno therapy’ by pharmaceutical companies, these include Mab drugs and cancer treatments. Checkpoint Inhibitor–Induced Colitis: A New Type of Inflammatory Bowel Disease? Madeline Bertha, MD MS, corresponding author1 Emanuelle Bellaguara, MD, Timothy Kuzel, MD, and Stephen Hanauer, MD ACG Case Rep J. 2017; 4: e112. Published online 2017 Oct 11. doi: 10.14309/crj.2017.112 PMCID: PMC5636906 PMID: 29043290

The Elderly

Mammal milk is required for enhanced phagocytosis as shown by research, especially in the elderly. Whole fat mammal milk can actually restore phagocytosis in senescent cells in the elderly. Phagocytosis, by which immune cells ‘eat’ bacteria or infected cells, is one of the mechanisms that help to resist infections. Lactic acid bacteria strains like acidophilus also increases phagocytosis.