Hydrogen Sulfide (H2S) SIBO
Hydrogen Sulfide (H2S) is a colorless gas that, owing to its sulfur content, smells like rotten eggs and is referred to as “sewer gas.”H2S affects the gut, liver, immune system, nerves, heart, and brain simultaneously. H2S is highly poisonous and the small intestine is much less efficient at detoxifying this gas.
- H2S is pro inﬂammatory
H2S affects the gastrointestinal smooth muscle cells and has a pro inflammatory effect. Donation of H2S contributes to chloride secretion, which aggravates certain types of gastritis. An increase in the steady state H2S levels is thought to play a role in the etiology of inflammatory bowel disease and related cancers. H2S has been termed rocket fuel for cancer in some leading university studies. H2S is also a byproduct of dietary sulfate metabolism by gut bacteria. Inflammatory bowel diseases such as ulcerative colitis are associated with an increase in the colonization by sulfate reducing bacteria along with an increase in H2S production.
- H2S as a gasotransmitter producing oxidative stress
- H2S can paralyze nerves and has an inhibitory effect on the ileum
Other health effects of SIBO
SIBO can produce a mild chronic encephalopathy.
SIBO related immunodeficiency syndromes – IgA Various immunodeficiency syndromes, such as IgA deficiency, common variable immunodeficiency, AIDS and others, are complicated by miscellaneous infection complications, including SIBO.
SIBO can cause severe malabsorption, serious malnutrition and deficiency syndromes.
Before SIBO was termed SIBO
Serum levels of folate and vitamin B12 may be used to support evidence of bacterial overgrowth in pediatric settings. This ratio was one of the first testing methods used to diagnose SIBO.
Infants who are not breastfed are at an early stage with SRB and with methane-forming bacteria settled.
Due to the difficulty in diagnosing SIBO, emerging molecular techniques in bacterial ‘fingerprinting’ may offer a more reliable way to define microbial populations in intestinal samples.
Cedars-Sinai investigators unveiled a new four-gas breath test device in 2018.
Cedars-Sinai investigators have identified a gas produced in gut that could improve the diagnosis and treatment of patients with two common intestinal illnesses—small intestine bacterial overgrowth (SIBO) and irritable bowel syndrome (IBS). Now a large-scale clinical trial has identified the presence of another gut gas—hydrogen sulfide—among these patients who experience diarrhea. Hydrogen sulfide appears to be linked to diarrhea,” said Mark Pimentel, MD, executive director of the Medically Associated Science and Technology (MAST) Program at Cedars-Sinai.
Two bacteria are now known to be the causative agents in SIBO.
E coli and Klebsiella
While both are normal inhabitants of intestinal flora in both humans and animals both are also considered to be contaminants and are associated with poor sanitation. Klebsiella can be a source of hospital outbreaks and food contamination. Both bacteria can be found on various produce, in baby formula and can occur as the result of processing various materials such as wood, paper, or other types of manufacturing. Sewage treatment and soil run off can also contribute to contamination.
date nut muffins
Date Nut Muffins are a classic British teatime treat made with sweet dates and toasted walnuts.
Date nut muffins are a handy variation on date nut bread, which originated in Great Britain (specifically Scotland) as a tea time treat. This recipe uses a small amount of brown sugar.