Alzheimer's - Diabetes of the Brain Caused by Fructose?

Greater research studies help show fructose as a major factor in cognitive decline.

Is high-fructose in our diet leading to Alzheimer’s? HealthCall’s Lee Kelso explores the possible connection with Richard J. Johnson, M.D., professor of medicine at the Division of Renal Diseases and Hypertension, University of Colorado’s Anschutz Medical Campus, and the lead author of a study on this topic. The discussion centers around how our bodies may be going wrong in an evolutionary survival mechanism that leads to neurological damage, and how fructose, a form of sugar found in high concentrations in many foods, can contribute to this mechanism. The conversation provides an interesting look at the role of fructose in our diets and its effect on our bodies.

Video commentary below.

Fructose metabolism and production, something awry or something revealing?

Why does this evolutionary switch occur in addition to hibernation or other states in life such as puberty or pregnancy where fat and energy storage is desirable to propagate the species?

Consensus appears to be building over the role of fructose as a contributor to cognitive decline from a larger pool of research. This video discusses not only added sugars but how the body can produce fructose as well.

That question hasn’t been answered in full in the above video but it does hint at starvation and diet as part of the process for both bears and our hunter gatherer human ancestors. 

My opinion is that like the ketosis switch where the body will burn an alternate fuel in the absence of glucose this switch to producing fructose is the result of a starvation/malnourishment state when the person isn’t seemingly under threat of actual starvation but is so malnourished by nutrient poor food that the body mistakenly thinks it is starving and therefore begins producing fructose as a compensatory mechanism to store fat instead of burning it as a last ditch alternative. It is likely not exactly the result of a faulty signal or something awry but more due to acute malnutrition as can be found in those who eat processed foods consisting mostly of cereals. This would be similar to the cognitive deficits as seen in Africa where cereal alone was often given in an attempt to prevent starvation. You can read more about the effects of this type of diet in Immune For Life.

At any rate it is interesting to see that other well defined studies are also shedding light on fructose metabolism and how this in turn affects cognitive function. On their part I’m sure it will be in an effort to develop a drug. The real point being is that you can use this knowledge to empower yourself.

Everyone thinks that increased fructose in fruit is desirable to attract consumers but is that true?
It would be interesting to learn if fructose production in plants has been altered or affected due to soil depletion resulting in another type of nutrient deficiency since fructose naturally plays a key role in energy production as well as the general health of plants. In other words do plants produce more fructose today as the result of ‘modern’ agriculture, soil depletion and stress or due to the desire to produce a sweeter product to attract consumers.
The bottom line almost always points to malnutrition instead of other downstream effects along the way and agriculture in general is producing less nutrient dense as well weaker species requiring more fertilizer and pesticides.
Similar to fructose production in humans but differentiating in that fructose in not a necessary molecule in humans as it is in plants could this just be another ‘side effect’ of poor plant health?

Remember, no more than 6 teaspoons (25 grams) of added sugar per day for women and 9 teaspoons (38 grams) for men. The AHA limits for children vary depending on their age and caloric needs, but range between 3-6 teaspoons (12 – 25 grams) per day. Children under two should have zero grams of sugar per day.
follow your gut

This recipe only has 1/4 cup of maple syrup and no other refined sugar.

  • 1 cup Grated Carrots (medium carrots)
  • ½ cup Chopped walnuts
  • ¼ cup Orange Juice
  • 1 ½ cups Whole wheat flour
  • 1 ¼ tsp Baking powder
  • ¼ cup Maple Syrup
  • ¼ cup Butter
  • 2 Eggs slightly beaten
  • ¼ cup warm Water
  • 1 tsp Cinnamon (or other spices if using)
  • 1 teaspoon Vanilla Paste Extract is fine if you don’t have the paste

Recipe link

More info

You can learn more info in about section regarding common gut/immune disorders, gcmaf and the library for research sources. Immune For Life is your complete guide to gut and immune health including how to make maf products, gentle formulas, recipes and more. Timeless gut/immune health and nutrition info that will protect you, no matter your age, your family and future generations.

Alternavita: All you need to know (critical info in a nutshell)..... by focusing exclusively on these foundational health and immune development issues up to 90% of chronic conditions can be eliminated.

WHO STATEMENTS: 2017 Millennium Goal

  1. Breastfeeding,
  2. food (security)
  3. and water security (sanitation)

are major protective factors against malnutrition and critical factors in the maturation of healthy gut microbiota, characterized by a transient bifidobacterial bloom before a global rise in anaerobes. Early depletion in gut Bifidobacterium longum, a typical maternal probiotic, known to inhibit pathogens, represents the first step in gut microbiota alteration associated with severe acute malnutrition (SAM). Later, the absence of the Healthy Mature Anaerobic Gut Microbiota (HMAGM) leads to deficient energy harvest, vitamin biosynthesis and immune protection, and is associated with diarrhea, malabsorption and systemic invasion by microbial pathogens. A therapeutic diet and infection treatment may be unable to restore bifidobacteria and HMAGM.


Researchers found that malnourished children’s microbiota failed to follow the healthy pattern they identified in healthy children. The microbiota of malnourished children is immature, lagging in development behind that of their healthy peers. Supplementing these children’s meals with widely used therapeutic foods that increase calories and nutrient density reduces deaths from malnutrition, but it does not fix their persistent microbiota immaturity.

“Perhaps more insidious than slowing growth is malnutrition’s effect on less visible aspects of health, including impaired brain development and dysfunctional immunity, which follow these children throughout their lives”.

The Father of The Microbiome

Dr. Jeffrey Gordon


SIBO can cause severe malabsorption, serious malnutrition and immune deficiency syndromes in children (non breastfed) and adults. 

Prognosis is usually serious, determined mostly by the underlying disease that led to SIBO.



The WHO recommends that immunization or treatment be orally administered due to economic, logistical and security reasons. Furthermore, this route offers important advantages over systemic administration, such as reducing side effects, as the molecules are administered locally and have the ability to stimulate the GALT immune responses  (Levine and Dougan, 1998Neutra and Kozlowski, 2006Bermúdez-Humarán et al., 2011).



For ANY infectious or parasitic disease to start, it is ALWAYS a requisite that the host suffer IMMUNODEFICIENCY. At the same time, infectious and parasitic diseases themselves cause additional IMMUNE SUPPRESSION and more MALNUTRITION. This immune suppression is SECONDARY to the accumulation of free radicals, especially oxidizing species, that occurs during and after infectious and parasitic diseases.

Clinical Aspects of Immunology and Biochem J.


Current IBD Research 2016

Currently available treatments for IBD, which target the systemic immune system, induce immunosuppression, thereby exposing the patient to the risk of infections and malignancy. The interplay between the gut and the systemic immune system determines the final effect on target organs, including the bowel mucosa. Inflammatory bowel diseases (IBD) are associated with an altered systemic immune response leading to inflammation-mediated damage to the gut and other organs.

Clinical & Translational Immunology (2016)
Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel

Most importantly, the immune modulatory agents used today for IBD do not achieve remission in many patients.

Not all IBD patients benefit from currently available drugs. Young people with IBD do not want to be on long-term drug therapy. Oral immune therapy, while not yet studied in large cohorts of patients, may provide an answer to this unmet need.

Clinical & Translational Immunology (2016)
Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel


Tolerance is the ability of the immune system to ‘see’ and respond appropriately. Without galactose (a necessary sugar) the immune system can not 'see'. Your immune system would not be able to function without galactose Your body wouldn’t know which cells are “good” and what cells are “bad.” Your body wouldn’t know who the invaders were and which ones should be attacked by antibodies. As you will learn the importance of these ‘sugars’ in gut microbiota health is a rapidly expanding field of research, only recently discovered, including HMO's (human milk oligosaccharides).

Why galactose? Milk sugar aka lactose has been shown to be very beneficial for the human body though unlike sucrose, lactose is made up of glucose and galactose. There is no fructose in lactose. It is a healthy disaccharide sugar. Galactose is known as the “brain sugar” and supports brain development of babies and children. Galactose helps triggers long-term memory formation. Galactose has been shown to inhibit tumor growth and stop its spread, particularly to the liver. This beneficial sugar can also enhance wound healing, decrease inflammation, enhances cellular communication, and increases calcium absorption.
What does immune ‘tolerance’ mean in simple language?
Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to substances or tissue that have the capacity to elicit an immune response in a given organism. The Th1 cytokine profile is vital for clearance of certain organisms and ancillary immune activity, and a limiting effect on this cytokine profile may result in reduced chances for overcoming infections especially intra-cellular organisms residing within macrophages. Effective clearance will depend on appropriate macrophage activation (which occurs through IFN≥ release by Th1 and NK cells) and production of nitric oxide. If this pathway is disrupted IFN≥ secretion is blocked, impairing macrophage activation. Persistent blockade of these inhibitory receptors has lead to the breakdown in immune self tolerance, thereby increasing susceptibility to autoimmune or auto-inflammatory side effects, including rash, colitis, hepatitis and endocrinopathies. Many drugs may cause checkpoint blockade toxicity including pharmaceutical drugs termed ‘immuno therapy’ by pharmaceutical companies, these include Mab drugs and cancer treatments. Checkpoint Inhibitor–Induced Colitis: A New Type of Inflammatory Bowel Disease? Madeline Bertha, MD MS, corresponding author1 Emanuelle Bellaguara, MD, Timothy Kuzel, MD, and Stephen Hanauer, MD ACG Case Rep J. 2017; 4: e112. Published online 2017 Oct 11. doi: 10.14309/crj.2017.112 PMCID: PMC5636906 PMID: 29043290

The Elderly

Mammal milk is required for enhanced phagocytosis as shown by research, especially in the elderly. Whole fat mammal milk can actually restore phagocytosis in senescent cells in the elderly. Phagocytosis, by which immune cells ‘eat’ bacteria or infected cells, is one of the mechanisms that help to resist infections. Lactic acid bacteria strains like acidophilus also increases phagocytosis.