Sources/Tips: Tips© Alternavita Magazine© September 2018


Alternavita Magazine© Sources/Tips Article Tips A serendipitous observation in the year 1995 that a casein fraction from human milk blocked the binding of bacteria to epithelial cell and was selectively toxic to a lung cancer cell line, evoked tremendous interest in the characterization of the tumoricidal molecule. The active fraction was soon traced to the casein fraction of human milk, obtained by acid precipitation and was subsequently identified as oleic acid (OA)-bound partially unfolded α-lactalbumin (α-LA). The complex was given the acronym HAMLET (Human αlactalbumin Made Lethal to Tumor cells). HAMLET exhibited broad tumoricidal activity against carcinomas, melanomas, glioblastomas and leukemias derived from human and various non-human sources. Other studies showed that HAMLET like complexes […]