There is no such thing as a safe, synthetic pharmaceutical, ALL chronic drug use contributes to liver failure, endocrine disorders, arthritis, inflammatory, autoimmune conditions, mental deterioration, AIDS, allergic conditions, rash, chronic malnutrition syndromes, IBD, checkpoint blockade toxicity, Cushing Syndrome, many other syndromes, endotoxemia, oxidative stress, cancer, overwhelming infection syndromes, chromosome damage, genetic damage, and early death. This includes most synthetic vitamins and many synthetic supplements. This also includes many herbal and so called ‘natural’ products that may still result in endotoxemia (this includes natural FtsZ inhibitors, turmeric, cinnamon, berberine which do not prevent endotoxins. Benzimidazoles (Rifaxamin also does not prevent endotoxins) . Bovine colostrum and a few other ‘functional’ food based medicaments are among the few exceptions that can be taken long term with no safety issues.