February 12, 2018©
This is the perfection of a man, to find out his own imperfections.
Is Boswellia As Effective As CBD Oil For Various Brain And Immune Disorders?
The present study was aimed to investigate the effect of Boswellia on cognitive impairment associated with Type II Diabetes induced in rats by high fat/high fructose (HF/HFr) diet.
Significant decrease Aβ deposits and p-tau positive cells after just three doses
That is Alzheimer’s, PTSD and traumatic brain injury (sports injury) which are associated with both Aβ and tau deposits.
Reverses high fructose and antibiotic induced injury
The effect of 3 doses of BS extract and the reference drug on the behavioral, biochemical, histopathological and glutamate gene expression abnormalities in Type II diabetes rates was evaluated. HF/HFr diet/ STZ induces learning and memory deficits, which were reversed by Boswellia extract.
It showed a significant decrease in Aβ deposits and p-tau positive cells.
Boswellia extract enhanced significantly the suppressed hippocampal level of GSH, SOD and glutamate receptor expression. In addition, BS extract alleviated insulin resistance and hyperlipidemia of Type II Diabetic rats. Our findings suggest that BS extract reversed learning and memory impairment in HF/ HFr diet / STZ induced diabetic rats.
This effect may be attributed to the inhibition of insulin resistance, pro-inflammatory cytokines, oxidative stress and hyperlipidemia.
- Boswellia alleviates fibrosis
- Boswellia alleviates kidney fibrosis
- Boswellia induces apoptosis
- Boswellia decreases inflammatory enzymes
- Boswellia is water soluble and highly lipophilic, similar to cbd oil
- Boswellia is a superior anti oxidant greatly reducing oxidative stress
Acetyl-11-keto-beta-boswellic acid (AKBA) is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree Boswellia serrata (frankincense).
It is possible that Boswellia offers comparable results to cbd oil for brain disorders.
The results can be stated that the Boswellia extract is offset by harmful effects of seizures on cognitive function and consumption of Boswellia extract increases the learning ability in epileptic animals.
2019 – Polyphenol-rich Boswellia serrata gum prevents cognitive impairment and insulin resistance through inhibition of GSK3β activity, oxidative stress and pro-inflammatory cytokines
Boswellia oleo gum resin
There are numerous active constituents in the gum resin of B. serrata. It contains the fatty acids palmitic, stearic, oleic, and linoleic. The anti-inflammatory activity is attributed to four triterpene pentacyclic acids commonly known as boswellic acids.
5-LOXIN® Boswellia serrata extract is a patent pending extract providing ten times as much AKBA as typical boswellia extracts. The extract is derived from the gum resin of the boswellia serrata plant, commonly known as frankincense. It is standardized to contain 30% AKBA (3-acetyl-11-keto-beta-boswellic acid).
Boswellia is poorly absorbed in the gut, and requires healthy fats (grass fed butter, olive oil, cod liver oil, fish oil, safflower oil) for better absorption. Boswellia also works better with yogurt, kefir, and whole fat mammal milk to enhance digestion. Inflammation will be greatly decreased by employing these additional methods.
Boswellia Blocks Allergic Response And DTH (delayed type hypersensitivity)
IgG are also involved in the regulation of allergic reactions. There are two pathways of systemic anaphylaxis: antigens can cause systemic anaphylaxis through classic pathway by cross-linking IgE bound to the mast cell receptor FcεRI, stimulating the release of both histamine and platelet activating factor (PAF). In the alternative pathway antigens form complexes with IgG, which then cross-link macrophage receptor FcγRIII, and stimulates only PAF release.
IgG antibodies can prevent IgE mediated anaphylaxis by intercepting a specific antigen before it binds to mast cell–associated IgE. Consequently, IgG antibodies block systemic anaphylaxis induced by small quantities of antigen but can mediate systemic anaphylaxis induced by larger quantities.
Histamine, which is associated with inflammation occurring during allergic reactions, can also be modulated by boswellia extracts.
Asthma is characterized by an increased production of leukotrienes, inflammatory mediators of the immune system. Boswellic acids inhibit the synthesis of these leukotrienes and other proinflammatory molecules.
One study found that taking 300 mg of bosewellia extract three times a day improved lung capacity and decreased asthmatic symptoms in 70% of patients.
Anti-anaphylactic and Mast Cell Stabilizing Activity:
Extract of gum resin of B. serrata containing 60% acetyl 11-keto beta boswellic acid (AKBA) along with other constituents such as 11-keto beta-boswellic acid (KBA), acetyl beta-boswellic acid and beta-boswellic acid has been evaluated for anti-anaphylactic and mast cell stabilizing activity inhibiting the anaphylaxis reaction in rats in dose-dependent manner.
However, the standard dexamethasone (0.27 mg/kg, p.o) revealed maximum inhibition of edema as compared to the extract. A significant inhibition in the compound 48/80 induced degranulation of mast cells in dose-dependent manner was observed thus showing mast cell stabilizing activity.
The standard disodium cromoglycate (50 mg/kg, ip) was found to demonstrate maximum per cent protection against degranulation as compared to the extract containing 60% AKBA.
Another study investigated the effect of Boswellic acids, a mixture of pentacyclic triterpene acids (BA) obtained from Boswellia serrata Roxb. on cell mediated and humoral components of the immune system and the immunotoxicological potential.
A single oral administration of BA (50–200 mg/kg) inhibited the expression of the 24 h delayed type hypersensitivity (DTH) reaction and primary humoral response to SRBC in mice. The secondary response was appreciably improved at lower doses.
In a multiple oral dose schedule BA (25, 50 and 100 mg/kg) reduced the development of the 24 h DTH reaction and complement fixing antibody titers and slightly enhanced the humoral antibody synthesis.
In concentrations greater than 3.9 μg/mL BA produced almost similar and dose related inhibition of proliferative responsiveness of splenocytes to mitogens and alloantigen. Preincubation of macrophages with different concentrations of BA enhanced the phagocytic function of adherent macrophages. Prolonged oral administration of BA (25–100 mg/kg/d×21 days) increased the body weight, total leukocyte counts and humoral antibody titers in rats.
It is not cytotoxic nor does it cause immunosuppression.
Boswellia Cancer Fighting Ability And Autophagy
In this study, we investigated the role of autophagy induced by boswellic acid analog BA145 on cell cycle progression in pancreatic cancer cells.
BA145 induced robust autophagy in pancreatic cancer cell line PANC-1 and exhibited cell proliferation inhibition by inducing cells to undergo G2/M arrest.
Inhibition of G2/M progression was associated with decreased expression of cyclin A, cyclin B, cyclin E, cdc2, cdc25c and CDK-1. Pre-treatment of cells with autophagy inhibitors or silencing the expression of key autophagy genes abrogated BA145 induced G2/M arrest and downregulation of cell cycle regulatory proteins. It was further observed that BA145 induced autophagy by targeting mTOR kinase (IC50 1 μM), leading to reduced expression of p-mTOR, p-p70S6K (T389), p-4EBP (T37/46) and p-S6 (S240/244). Notably, inhibition of mTOR signalling by BA145 was followed by attendant activation of AKT and its membrane translocation. Inhibition of Akt through pharmacological inhibitors or siRNAs enhanced BA145 mediated autophagy, G2/M arrest and reduced expression of G2/M regulators. Further studies revealed that BA145 arbitrated inhibition of mTOR led to the activation of Akt through IGFR/PI3k/Akt feedback loop. Intervention in IGFR/PI3k/Akt loop further depreciated Akt phosphorylation and its membrane translocation that culminates in augmented autophagy with concomitant G2/M arrest and cell death.
In conclusion Boswellia:
- is anti-inflammatory,
- is anti allergy (by blocking classic IgG pathway cascade)
- reverses insulin resistance
- promotes apoptosis
- prevents and reverses amyloid and tau protein toxicity and plaque
- is an anti depressant
Boswellia requires oil for better transport.
Don’t use essential oil Frankincense, it is a volatile oil.