February 21, 2019©
No more assumptions should be made than are necessary.
William of Ockham
Colostrum For The Treatment Of Chronic Pain Syndromes
In certain chronic pain syndromes it is previously known that antibodies against endotoxin may be used in the treatment. Endotoxins are degradation products of bacteria that can cause numerous physiological responses in humans. Lipopolysaccharides are compounds from fat-like (lipo) constituents and sugar components (polysaccharides). They are, for example, in the outer membrane of gram-negative bacteria contain and act as antigens. The decay of the bacteria parts of the lipopolysaccharide are freed and have a toxic effect. These parts are called endotoxins.
Raised LPS levels occur mainly in patients with Gram-negative bacterial infections who have been treated with bacteriocidal antibiotics.
For any infectious or parasitic disease to start, it is always a requisite that the host suffer IMMUNODEFICIENCY. At the same time, infectious and parasitic diseases themselves cause additional IMMUNE SUPPRESSION and more MALNUTRITION. This immune suppression is SECONDARY to the accumulation of free radicals, especially oxidizing species, that occurs during and after infectious and parasitic diseases.
Clinical Aspects of Immunology and Biochem J.
Antibodies against endotoxins are also contained in the natural spectrum of antibodies from bovine colostrum.
The erroneous processing of bacterial antigens, especially in the monocytes a sufficient degree of “organized cell death,” ie, apoptosis is initiated that upon receiving the antigen to immune cells of the mucous membranes. Apoptosis normally leads to local neutralization of toxins within the immune barrier of the digestive tract.
These immune cells do not after the toxin uptake – as it would have been normally expected – go into apoptosis. In close correlation to this finding in the cellular immune system, atypical for this disease mechanism is a defective humoral immune response in serum or plasma of patients.
A therapeutic and / or prophylactic effect in the use of an agent consisting of antibodies, antibody portions, insulin like growth factor antagonist and / or Toll-like receptor antagonists could now be useful in patients with chronic pain syndrome. The results of the conducted clinical studies for the first time show therapeutic effects in co-morbidities of the study patients. It was surprisingly shown also the first time with endotoxin pain syndromes but also with typical symptoms of known diseases may play a pathogenetic role not only in the initiation and maintenance of chronic but previously idiopathic pain syndromes.
Bovine colostrum has been proven for the treatment of diseases selected from the group consisting of polyneuropathy, mononeuropathy (possibly without trigeminal neuralgia), autonomic neuropathy, small fiber neuropathy and especially each of the autoimmune diseases, diabetes mellitus type I and II diabetes type A, B, C, D, E, F, G, H, polyclonal gammopathy and/or kidney dysfunction along with many other chronic pain syndromes.
Bovine colostrum reduces both the gene expression of TLR’s and pro-inflammatory cytokines in the small intestine.
Bovine colostrum whey protects the integrity of the intestinal mucosal barrier by inhibiting the expression levels of inflammatory genes following the invasion by enteric bacterial pathogens. Colostrum proteins inhibit NF-κB-mediated pro-inflammatory cytokine expression and switch off markers of inflammation. Colostrum blocks IL-1β-induced pro-inflammatory gene expression and COX-2 protein expression in human colon cancer cell line HT-29 through an inhibition of NF-κB signaling pathway. Moreover, Bovine colostrum contains considerable high levels of IgG. The central role of Igs in the intestine is to bind the bacteria, in particular the pathogens, with a mechanism called exclusion. In this way, the bacteria can not enter into contact with the intestinal epithelium and it is reduced the continuous antigenic stimulation from the gut-derived bacterial endotoxin such as LPS, favoring the maintenance of a state of tolerance. Moreover, Igs can maintain the intestinal barrier functions reducing the risk of inflammation and bacterial translocation. The inhibitory cytokines IL-10, TGFβ and IL-35 are considered to be Tregs pivotal mechanism of annihilating pro-inflammatory cytokines secretion of other immune cell types.
Bovine colostrum is a rich source of biologically active molecules that are essential for several specific functions of digestive system and, at the same time, that can synergistically intervene in various pathogenetic phases of the IBD. Bovine colostrum has the potential to modulate the immunological response as well as the severity of the intestinal inflammatory reaction modulating TLR’s and cytokine expression, balancing the microbiota. Moreover, BC seems a suitable candidate to be used as a natural supplement that may reduce the side effects of the synthetic drugs that are currently used in the treatment of IBD and other digestive system diseases.
In International Journal Clinical Pharmacology Therapy, 2008 May. 46 clinical studies are disclosed with bovine colostrum.
In International Journal Clinical Pharmacology Therapy, 2009 July is disclosed the treatment of patients with chronic pain syndrome with oral immunoglobulin from bovine colostrum.
In A. Goebel et al. discloses data showing an increased permeability in the gastroduo- denalen area and in the small intestine in the presence of two chronic pain syndromes (fibromyalgia and complex regional pain syndrome).
IBD is a dysfunctional autophagic system
- Intestinal barrier loss alone is insufficient to initiate disease.
Currently available treatments for IBD, which target the systemic immune system, induce immunosuppression, thereby exposing the patient to the risk of infections and malignancy.
The interplay between the gut and the systemic immune system determines the final effect on target organs, including the bowel mucosa.
Inflammatory bowel diseases (IBD) are associated with an altered systemic immune response leading to inflammation-mediated damage to the gut and other organs.
Clinical & Translational Immunology (2016)
Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel
Among most mammals, the placenta is not effective at transferring antibodies to the fetus: antibodies are transferred immediately after birth via the colostrum.
In fact, the WHO recommends that immunization or treatment be orally administered due to economic, logistical and security reasons. Furthermore, this route offers important advantages over systemic administration, such as reducing side effects, as the molecules are administered locally and have the ability to stimulate the GALT immune responses (Levine and Dougan, 1998; Neutra and Kozlowski, 2006; Bermúdez-Humarán et al., 2011).
All patients reflected in the above patent application were successfully treated with antibodies to endotoxins from natural sources such as egg yolks or bovine colostrum. The European patent process for this product has ceased. Colostrum is a natural substance.
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Bovine serum albumin (IGG)(Immune Factor-Toxin Binder)