Alternavita Daily August 2018©

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Alternavita Daily

August 25, 2018©

Recap: Milk Proteins And Sugars

Milk serum proteins are defined as substances that remain soluble in milk serum. These proteins are naturally formed during the production of cheese and account for 20% of the all protein in milk, such as:

  • β-lactoglobulins
  • α-lactalbumin
  • immunoglobulins
  • lactoferrin
  • lactoperoxidase
  • glycomacropeptide
  • bovine serum albumin
  • and other proteins

Milk serum proteins are rapidly digested, and raise plasma amino acid concentrations. Therefore, milk serum proteins perform several functions, such as mineral absorption, improvement of protein synthesis, sensitivity to hormones, and decreased blood glucose and lipid levels.

Sweet whey is a byproduct produced during the manufacture of rennet types of hard cheese, like Cheddar or Swiss cheese. Acid whey (also known as sour whey) is a byproduct produced during the making of acid types of dairy products, such as cottage cheese or strained yogurt.

Components And Action Of Whey Proteins On Immune Function

Immunoglobulin (10–15%)

Four classes of immunoglobulins are present in serum: IgG, IgA, IgM, and IgE. It functions as an antioxidant protection and increases immunity.

  • IgM is in the first line of immune system defense.
  • IgA are common antibodies in mucosal areas such as the nose, lungs, eyes and ears. They prevent mucosal infections by causing microbes to agglutinate (clump). In the intestine, IgA is an immunosuppressant that inhibits proinflammatory responses to oral antigens. IgA deficiency is common.
  • IgG antibodies inactivate harmful infectious organisms by binding to them. This reduces or eliminates microbes’ ability to cause illness. IgG binds toxins.

Whey Protein Can Enhance Innate Immunity by Priming Normal Human Blood Neutrophils

Galactose

  • Severely ill diabetic patients have a decreased amount of galactose and sialic acid on their Easy Home Made Yogurtbuccal cells, compared with minimally ill patients and healthy controls.

Galactose has been shown to be a very beneficial sugar that is actually an essential nutrient for the human body.

Milk sugar aka lactose has been shown to be very beneficial for the human body though unlike sucrose, lactose is made up of glucose and galactose. There is no fructose in lactose. It is a healthy disaccharide sugar.

β-galactosidase, also called lactase is important for organisms as a key provider in the production of energy and a source of carbons through the break down of lactose to galactose and glucose. It is also important for the lactose intolerant as many adult humans lack the lactase enzyme, which has the same function of beta-gal, so they are not able to properly digest dairy products.

Kefir grains show β-galactosidase enzyme activity, which stays active when consumed. β galactosidase enzymes found in kefir and yogurt are able to convert gc globulin protein to macrophage activating factors during the fermentation process. β-Galactosidase treatment is a common first-stage modification of the three major subtypes of Gc protein to GcMAF (a popular and effective immune therapy treatment).

Galactose is known as the “brain sugar” and supports brain development of babies and children. Galactose helps triggers long-term memory formation. Galactose has been shown to inhibit tumor growth and stop its spread, particularly to the liver. This beneficial sugar can also enhance wound healing, decrease inflammation, enhances cellular communication, and increases calcium absorption.

  • Of the milk sugars, galactose, but not prebiotic galacto-oligosaccharide (GOS), improves insulin sensitivity. Intake of galacto-oligosaccharides (GOS) improved the gut microbial profile but did not improve insulin sensitivity.

Your Immune System Would Not Be Able To Function Without Galactose

  • Your body wouldn’t know which cells are “good” and what cells are “bad.” Your body wouldn’t know who the invaders were and which ones should be attacked by antibodies.

Acid whey contains more than twice the amount of galactose as ‘sweet’ or ‘cheese whey’ making it a beneficial addition to the control of insulin resistance, diabetes, metabolic syndrome and perhaps obesity.

Alpha-lactalbumin

How does whey protein enhance GSH? Alpha-lactalbumin, a whey protein, contains high levels of cysteine, an amino acid used to make glutathione.

Sulfur amino acids are linked but they are not entirely interchangeable. The bioavailability of cysteine is rate limiting for glutathione synthesis. Cysteine is generally considered a nonessential or dispensable amino acid in adults because it can be synthesized from the essential amino acid methionine. Methionine is central to 1-carbon metabolism, which requires folate, vitamin B12, and choline and is essential for synthesis of the purines, pyrimidines, and polyamines required for nuclear development and function, while cysteine is essential for synthesis of taurine and glutathione, which are involved in immune and antioxidant responses. Methionine can be resynthesized from homocysteine by remethylation, but conversion of cystathionine to cysteine is irreversible.

Alpha-lactalbumin is rapidly digested in the small intestine. Bovine Alpha-lactalbumin is found in bovine colostrum, mammal milk and whey.

Why do we want GSH?

GSH is an extremely powerful internal antioxidant that enhances health in numerous ways.

Glutathione (GSH) is a primary endogenous antioxidant.

  • GSH redox imbalance in brain disorders have been well studied and can be considered as a bio marker.  

GSH depletion and GSH-related enzyme deficit are involved in the pathology of brain disorders such as autism, schizophrenia, bipolar disorder, Alzheimer’s disease, and Parkinson’s disease.

Humans with neurodegenerative and neuropsychiatric disorders have altered levels of GSH and oxidized glutathione (GSSG), decreased ratio of GSH/GSSG and impaired expressions of GSH-related enzymes in the blood or brain. GSH depletion can lead to abnormalities in methylation metabolism and mitochondrial function. Some studies have shown that a GSH deficit occurs prior to abnormalities in these diseases.

Alpha-lactalbumin In Acid Whey

Alpha-lactalbumin is a bioactive milk protein found in acid whey, typically containing 20-25% α-LA. This is nearly equal to that found in human breast milk.

When α-LA is broken down (hydrolyzed) by the body it releases cysteine. Cysteine is a precursor to glutathione (GSH), a vital internal antioxidant. Alpha-lactalbumin has a direct effect on the body. It increases production of serotonin and glutathione. Alpha-lactalbumin increases liver glutathione after strenuous exercise.

  • Whey protein increased lymphocyte glutathione (GSH) in humans.
  • Oral administration of substantive amounts of bovine whey protein enhances the glutathione content in the liver, heart and spleen. This change is moderate but sustained over time and biologically significant.

This property is restricted to the undenatured conforma­tion of whey protein.

  • The administration of glutathione itself is of little consequence on tissue glutathione levels, because it  cannot be transported intact across the cell membrane. Some methods of increasing intracellular levels of glutathione concentration are either toxic or dangerous owing to the risks related to the initial phase of glutathione depletion.

  • Undenatured whey protein of bovine origin increases glutathione in various tissues.

Powdered whey bodybuilding supplements are not un-denatured. The word “denatured” is a biochemical process in which proteins lose their structure.

Only Whey Protein Or Diets That Contain This Protein Improve Antioxidant Function

Whey proteins, when compared with other dietary proteins (ie, soy, casein, or wheat), have been shown to enhance antibody production.

When L. lactis ssp. lactis is added to milk, the bacterium uses enzymes to produce energy molecules (ATP), from lactose. The byproduct of ATP energy production is lactic acid.

Microglial Cells

Microglial cells are the resident macrophages of the central nervous system (CNS), including the retina, and play a pivotal role in innate immune responses and regulation of homeostasis in the healthy and degenerating CNS.
Despite being cells of the mononuclear phagocyte lineage, their CNS-specific location and morphology clearly distinguishes them from other macrophage populations.
  • Acid Whey Reverses Neurodegenerative And Retina Inflammation By Activating CNS Macrophages 

Oleic Acid Is Necessary For Proper Brain Function

What is Oleic Acid?

  • One of the most common fats in human breast milk
  • Makes up 25% of fat in cow’s milk
  • Alpha-lactalbumin joins with oleic acid to fight cancer cells (HAMLET)

Myelin is a protective covering or sheath that twists around nerves (neurons), including nerves in the brain. Myelin is made of 70% fat and 30% protein. Oleic acid is one of the most common fats in myelin.

Oleic acid doesn’t just help synthesize myelin, it is also a cell signaling molecule. Oleic acid regulates cholesterol and lipogenesis (making fat) in the brain.

The ability of whey proteins to increase glutathione concentrations and enhance immunity, along with the discovery of the unique antitumor complex called HAMLET (Human Alpha-lactalbumin Made Lethal to Tumor cells).

  • BAMLET is actually shown to be more effective than HAMLET.

Bovine Alpha-lactalbumin is more effective than Human Alpha-lactalbumin.

Bioactive peptides present in milk whey are one of the most studied compounds in different dairy products. Bioactive peptides from dairy sources are majorly classified on the basis of their biological roles as anti-hypertensive, anti-oxidative, immmuno-modulant, anti-mutagenic, anti-microbial, opioid, anti-thrombotic, anti-obesity and mineral-binding agents. These bioactive peptides are produced by enzymatic hydrolysis during fermentation and gastrointestinal digestion. Thus, fermented dairy products like yogurt, cheese and buttermilk are gaining popularity worldwide and are considered as an excellent source of dairy peptides. Furthermore, these dairy products are also associated with lower risks of hypertension, coagulopathy, stroke and cancer.

Note:

Some genetically susceptible individuals may react badly to milk products but this is considered a very rare occurrence and is usually suspected and confirmed while the subject is very young. Intolerance can develop for many reasons later in life not related to severe inherent genetic problems. Galactosemia is one such genetic enzymatic dysfunction that can be investigated before undertaking any mammal milk therapy. Confirmed severe lactose or casein allergy can also prevent undertaking mammal milk therapeutics. Age related decline in tolerance is not a hindrance in most cases as the human body can recover lost digestive capability and humans can naturally eat a variety of foods. Bovine colostrum is generally not included among most milk intolerance problems but one should ensure avoidance of all mammal milk products if there is potential for a severe outcome due to an inherent, irreversible, genetic or other severe clinically confirmed allergic problem.

General widespread food intolerances, malabsorption and chronic malnutrition can become severe due to extensive intestinal damage such as found in SIBO, IBD and Crohn’s, prognosis is poor in these syndromes with current clinical approaches.

Click the links below to read more about:

Alpha-lactalbumin And Cancer©

Alpha-lactalbumin Bioactive Protein©

Whey Protein And Severe Brain Disorders©

A Whey Protein Diet Promotes Longevity©

Feed The Good Bacteria In The Colon©

Acid Whey For Gut Health, Mental Health And Quickly Fighting Obesity©

Natural Immune Benefits In Whey©

Protein Vs. Protein – Forget Paleo And Opt For Functional Proteins©

Cardiovascular Disease Is Responsible For 30% Of Deaths Worldwide©

Probiotic Capsules Without Milk Are Virtually Useless©

Acid Whey Reverses Neurodegenerative And Retina Inflammation By Activating CNS Macrophages

Diabetes Control And Dairy Sugars©

Dietary Whey Protein Lessens Many Risk Factors For Metabolic Diseases©

Unproven Lyme Treatments Cause Serious Life-threatening Adverse Effects

To learn how to take optimal health advantage of all bio active milk peptides, sugars, probiotics and friendly yeasts read more here

 

August 23, 2018©

Alpha-lactalbumin And Cancer

The ability of whey proteins to increase glutathione concentrations and enhance immunity, along with the discovery of the unique antitumor complex called HAMLET (Human Alpha-lactalbumin Made Lethal to Tumor cells), led scientists to investigate the potential use of whey proteins in cancer therapy. A diet formulated with whey protein concentrate, when compared with a standard casein-based diet, reduced the incidence and size of chemically induced colon tumors.

Whey protein had twice the protective effect of soy protein

This finding was replicated, showing that whey protein had twice the protective effect of soy protein. The anticarcinogenic properties of whey protein have also been demonstrated with  mammary tumors. The authors speculated that the beneficial effects of whey protein could be associated with enhanced tissue glutathione levels or active peptides. In support of the glutathione mechanism it was shown that increased cellular glutathione concentrations protected cells against reactive oxygen species and cell death.

HAMLET was discovered serendipitously in a pneumonia experiment

The HAMLET complex was discovered by researchers examining the potential of dairy protein extracts to reduce the adhesion of pneumonia-causing bacteria to respiratory epithelial cells. When these investigators serendipitously switched their cell line to lung carcinoma cells, they found that the dairy protein product killed both the bacteria and the cancer cells. Investigating this apoptotic response further, they fractionated the dairy product and isolated the active compound, identifying it as a protein-lipid complex of α-lactalbumin and oleic acid, which they named HAMLET.

HAMLET is a potent anticancer agent in over 50 cancer cell types

HAMLET is a potent anticancer agent, killing tumor cells of approximately 50 cancer cell types with high selectivity while leaving healthy cells largely unaffected both in vitro and in vivo. The structure of HAMLET compounds consists of an aggregation of partially unfolded proteins with fatty acid molecules bound in the hydrophobic core. Similarly, BAMLET (Bovine Alpha-Lactalbumin Made Lethal to Tumor), a complex of bovine α-lactalbumin and oleic acid, also kills tumor cells, and both HAMLET and BAMLET appear to penetrate the cell membrane and trigger a pathway for lysosomal cell death. α-Lactalbumin–oleic acid complexes such as HAMLET and BAMLET appear to have the ability to kill tumors cells that are otherwise highly resistant to apoptosis.

HAMLET (or BAMLET) is not a normal component of milk but is formed during low-pH precipitation of the casein fraction, which allows for partial unfolding of the α-lactalbumin structure and binding with the fatty acid.  There is debate over whether the key cytotoxic component of HAMLET/BAMLET complexes is α-lactalbumin or oleic acid. Some studies suggest the oleic acid component of these complexes accounts for the cytotoxicity, with α-lactalbumin acting only as a solubilizing agent that enhances membrane permeability for the fatty acid. Although a binding site for oleic acid was identified in the α-lactalbumin molecule, several other proteins, such as milk lysozyme, apomyoglobin, and α-2-microglobulin, also form HAMLET-like complexes with oleic acid and show antitumor activity.

Oleic acid is the transport molecule for the complex HAMLET

In conclusion, the protein component is not the cytotoxic component of the HAMLET protein–oleic acid complex but instead is involved in the delivery of cytotoxic oleic acid across the tumor cell membrane. HAMLET complex can be formed in the absence of oleic acid.

In humans with therapy-resistant skin papillomas, topical application of HAMLET significantly reduced lesion size and eliminated all lesions in over 80% of patients within 2 years. In patients diagnosed with superficial bladder cancer HAMLET reduced tumor cell size and increased tumor cell apoptosis. In rats transplanted with human glioblastoma cells, local infusion of HAMLET delayed tumor development, and the HAMLET complex appeared to penetrate the tumor, triggering apoptosis. In colon cancer, investigators found that oral delivery of HAMLET produced a significant reduction in tumor size and polyp number.

Oleic Acid Is Necessary For Proper Brain Function

What is Oleic Acid?

  • One of the most common fats in human breast milk
  • Makes up 25% of fat in cow’s milk

Myelin is a protective covering or sheath that twists around nerves (neurons), including nerves in the brain. Myelin is made of 70% fat and 30% protein. Oleic acid is one of the most common fats in myelin.

Oleic acid doesn’t just help synthesize myelin, it is also a cell signaling molecule. Oleic acid regulates cholesterol and lipogenesis (making fat) in the brain. A  diet high in monounsaturated fats (including oleic acid) reduces age-related changes in the brain’s mitochondria.

Fatty acid composition in the postmortem amygdala of patients with schizophrenia, bipolar disorder, major depressive disorder, Alzheimer’s disease or mild cognitive impairment showed a mild to severe (up to 80%) decline of oleic acid concentration as compared to those with no cognitive impairment.

BAMLET is actually shown to be more effective than HAMLET.

Bovine Alpha-lactalbumin is more effective than Human Alpha-lactalbumin.

June 2018

Alpha-lactalbumin is a bioactive milk protein found in acid whey. It is currently under investigation as a food additive for infant formula in an effort to make infant formula more like human breast milk. Several recent infant formula additives like lactoferrin, while beneficial do not necessarily improve important health outcomes such as obesity and other in inherent neurological, metabolic and necrotic syndrome problems related to infant formula vs. superior health outcome breast feeding. An intensive investigative research effort is rapidly underway to create infant formula that produces outcomes similar to breast feeding as the complexities of human breast milk can not be replicated. Lactose besides being an important sugar molecule with a variety of functions is necessary for mammal milk formation.

Tip:

I serendipitously discovered the benefits of acid whey when we suddenly produced cup after cup of it for bread making and didn’t want to waste this viable product. It produces the most wonderful bread texture. While I don’t use acid whey for fermenting vegetables I do use it for many other benefits. I simple add it to milk as an extra rapidly absorbed protein boost. Sometimes I use it as a starter for juice but I primarily eat my fruit whole and skip juice unless I use a very powerful juice extractor that leaves only juice and no pulp. It is beneficial to add fruit to kefir or yogurt for a day to pre-digest and release important vitamins and components. It also increases friendly yeasts that are found in the peel or skins of fruits. All vitamins and minerals including vitamin C are produced by organisms via kefir fermentation or naturally found in kefir so I don’t consume a lot of fruit. Milk is my go to source for energy and benefit and I don’t obtain any medicine from medicine but make my own superior bio active functional foods at home and the majority begin with dairy. Kefir generally has a shelf life of about two months, the majority of these mass produced functional foods as nutraceuticals or medicine (colostrum not included) have a far shorter shelf life.

It is important to remember that all dairy components are beneficial and it is not necessarily a correct assumption that one separated from the whole is better or worse, research is for the researchers, mass marketing is for the producers, to keep their paychecks coming and while a topic of interest to learn how things work personally, for the average lay person it is enough to know that they do as they always have throughout history. A very long history.

I do like helping farmers who often reap the lowest profits while producing the most benefits to society. I also like helping poor and ignorant people to help quickly understand and alleviate chronic malnutrition syndromes. Unfortunately, most do not understand how these problems begin and are increased exponentially in generational fashion but are reversed quite quickly and very inexpensively once they do. It is also of benefit to society to reduce waste so whey is an important topic as a waste byproduct.

In fact, the top, newest, most used and most expensive MS drugs left me bedridden the majority of the time unable to care for myself or my family.

My total yearly supplement bill for an entire family and pets is less than $70 per year today. I assume that does not make the industrial medical complex too happy as it was a general cost reduction from about 60K per year or more if you deduct testing. I also reduced my grocery bill about by about $200 per month with a few simple changes. I am busy, I prefer simple.

The hardest part is in convincing people the benefits are increased and sustained over time. It takes 30 days to establish a habit, it takes over 90 days to institute a lifestyle. In today’s instant gratification society, that is the hardest part.

Alpha-lactalbumin is rapidly digested in the small intestine. Bovine Alpha-lactalbumin is found in bovine colostrum, mammal milk and whey.

Alpha-lactalbumin is helpful in guarding against several organisms including shigella, e coli and Candida.

Synthesis of beta-lactoglobulin and alpha-lactalbumin in cow and sheep colostrum and milk throughout early lactation have been studied. Both proteins was similar in cow and sheep species. The highest concentration was found in the first milking (19 and 2 mg/ml for beta-lactoglobulin and alpha-lactalbumin, respectively).

Learn how to make a super healthy version of acid whey with high amounts of undenatured Alpha-lactalbumin and more beneficial probiotics and friendly yeasts than can be usually found in acid whey products here©.

August 22, 2018©

Alpha-lactalbumin Bioactive Protein

Alpha-lactalbumin is a bioactive milk protein found in acid whey. Whey protein typically contains 20-25% α-LA.  Human breast milk contains 36% α-LA.  Cow milk contains approximately 284 mg α-LA in 1 cup (8 oz.)(236 ml.).

Human and bovine α-lactalbumins share similar amino acid compositions, having 74% sequence homology and similar bioactivities.

α-Lactalbumin is digested in the small intestine, where amino acids are absorbed both individually and as small peptides.

When α-LA is broken down it releases cysteine and tryptophan, two essential amino acids. Alpha-lactalbumin contains 6% tryptophan, which makes it the best food source of this important amino acid.

Tryptophan is is necessary for serotonin production

Tryptophan is is necessary for serotonin production. Serotonin is a neurotransmitter which also reduces appetite and suppresses pain perception. It is involved in many functions including mood, behavior, appetite, bone metabolism, aging, wound healing, endocrine regulation, sleep, memory, learning, temperature, muscle contractions and cardiovascular functions. Depression is associated with lower concentrations of brain serotonin.

Serotonin does not cross the blood–brain barrier, so it must be synthesized within the brain, and synthesis is in large part dependent on the availability of tryptophan. Tryptophan is transported into the brain by the large neutral amino acid (LNAA) carrier, which also transports the BCAAs (leucine, isoleucine, and valine), phenylalanine, and tyrosine.

When α-LA is hydrolyzed it releases cysteine. Cysteine is a precursor to glutathione (GSH), a vital internal antioxidant.

α-Lactalbumin is the second most abundant protein in bovine-derived whey protein concentrates and whey protein isolates, accounting for 15% to 20% of total protein. It is available commercially as α-lactalbumin–enriched whey protein concentrates obtained by filtration methods, with α-lactalbumin constituting approximately 45% of total protein. Highly purified α-lactalbumin, accounting for more than 93% of total protein, is obtained by ion exchange methods. α-Lactalbumin preparations have physical properties and food system behaviors similar to those of whey protein isolates, including high protein quality, clean flavor profile, high water solubility across a wide pH range (2.0 – 9.0), and heat stability, making them compatible for use in beverages.

It is difficult to obtain purified proteins with the processes used for isolation

While whey protein isolate is widely used in adult nutrition, specific whey proteins, such as α-lactalbumin, have received relatively little attention for use in adult nutrition, in part because it is difficult to obtain purified proteins with the processes used for isolation. However, recent advances in large-scale ion exchange and filtration methods have led to highly purified α-lactalbumin (> 93%) that is free of other proteins and lipids.

High-purity α-lactalbumin allows researchers to further evaluate the nutritional value of α-lactalbumin as well as its unique amino acid profile and bioactive peptides. Currently, most research on α-lactalbumin for adult nutrition has focused on whether the high tryptophan content of α-lactalbumin can be leveraged to modify neurological or behavioral outcomes such as sleep and mood.

More Alpha-lactalbumin Benefits

α-LA stimulates phagocytosis by human macrophages.

Acid whey reverses neurodegenerative and retina inflammation by activating CNS macrophages. 

Alpha-lactalbumin joins with oleic acid to fight cancer cells

Oleic acid is a monounsaturated fatty acid also found in milk. It binds to milk proteins, such as α-lactalbumin and lactoferrin, to form potent complexes. These compounds have selective anti-tumor activity against malignant cancerous cells but are nontoxic for normal cells  (2018).

More Alpha-lactalbumin Immune Benefits

Whey proteins, because of their unique amino acid composition, are recognized for their ability to optimize aspects of immune function, with their best-characterized action being stimulation of glutathione and glutamine production. Glutathione is synthesized from cysteine, glutamate, and glycine. It plays a major role in protection of cells against oxidative stress. Glutamine is produced in skeletal muscle from catabolism of BCAAs and is an essential fuel for the immune system.

Diets supplemented with dairy (ie, milk or yogurt) or whey protein have been shown to increase tissue levels of glutathione. Kefir is clinically proven to decrease fatigue and increase glutathione.

Glutathione plays a central role in the body’s ability to scavenge reactive oxygen species and also has diverse roles in signal transduction, gene expression, apoptosis, and nitric oxide metabolism. Depletion of tissue glutathione is observed in a wide range of physical stress conditions, ranging from intense exercise and aging to pathologies such as cancer, neurodegenerative disorders and cystic fibrosis. Diets supplemented with dairy (ie, milk or yogurt) or whey protein have been shown to increase tissue levels of glutathione.

The bioavailability of cysteine is rate limiting for glutathione synthesis. Cysteine is generally considered a nonessential or dispensable amino acid in adults because it can be synthesized from the essential amino acid methionine. While nutritional requirements for these 2 sulfur-containing amino acids are often listed together as a sum, methionine and cysteine participate in different metabolic processes. Methionine is central to 1-carbon metabolism, which requires folate, vitamin B12, and choline and is essential for synthesis of the purines, pyrimidines, and polyamines required for nuclear development and function, while cysteine is essential for synthesis of taurine and glutathione, which are involved in immune and antioxidant responses.

The first step in cysteine synthesis is transmethylation of methionine to homocysteine, which is then combined with serine to form cystathionine. Cystathionine is subsequently converted to cysteine. Methionine can be resynthesized from homocysteine by remethylation, but conversion of cystathionine to cysteine is irreversible. Hence, while the sulfur amino acids are linked, they are not entirely interchangeable, and some investigators suggest that diet is limiting in cysteine availability. Elevated plasma concentrations of homocysteine are associated with increased risk of cardiovascular disease, while increased levels of glutathione appear to reduce the risk of cardiovascular disease.

Dietary supplements of cysteine increase glutathione levels without increasing homocysteine

Whey proteins also provide a rich source of cysteine with relatively lower levels of methionine. Most proteins have a ratio of cysteine to methionine that is higher in methionine, but whey protein has a cysteine-to-methionine ratio of approximately 1.3, and α-lactalbumin has a cysteine-to-methionine ratio of approximately 4.8. The cysteine present in α-lactalbumin occurs in the form of 4 disulfide bridges that can be released by digestion and appear in the blood as either the disulfide cystine or free cysteine.

Whey proteins, when compared with other dietary proteins (ie, soy, casein, or wheat), have been shown to enhance antibody production

Furthermore, animal studies demonstrate that consumption of α-lactalbumin protein can increase liver glutathione in a dose-dependent response and can increase total white cell counts (CD4+) and lymphocyte counts in mice with parasitic infections. Studies have also shown that glutathione can modulate glucose tolerance and improve insulin sensitivity, through a mechanism of nitric oxide signal transmission.

In humans, increasing the supply of cysteine or cystine can increase glutathione synthesis and prevent glutathione deficiency under nutritional or pathological stress (ie, protein malnutrition, respiratory distress, or  infection). Several studies found that supplementing with cysteine-rich whey proteins increased blood levels of glutathione.

Alpha-lactalbumin And Infant Formula

Addition α-lactalbumin to infant formula as compared to standard infant formulations provides metabolic profiles more similar to breast fed infants with decreased obesity and other metabolic syndrome outcomes.

Poor protein synthesis is a detrimental outcome of formula feeding. Read more about PCM and the negative effects of formula feeding here.

Human breast milk and colostrum as complex substances can not be replicated but intense research is now focusing on ways to produce outcomes more similar to those as found in the breast fed infant. The optimally breast fed infant is the gold standard of infant and animal care as outlined by WHO.

Current research on Alpha-lactalbumin as a food additive is focused on seizure and epilepsy reduction as well as decreased entero infections like e coli as well as reduction of metabolic syndromes, poor protein synthesis, increased nutritional benefit, reversal of chronic malnutrition syndromes like PCM, decreased immune deficiency syndromes and various mental issues like depression syndromes.

This work would not be possible without the discoveries of natural immune therapy gcmaf, the work of Dr. Nobuto Yamamoto (whey protein recommended along with gcmaf), Dr. Marco Ruggiero, Cedars Sinai and many others who understand the dire life long health consequences in the formula fed, non breast fed, sub optimal breast fed and premature infant.

Tip: 

Obtaining acid whey at home has a superior advantage as industrial methods to obtain protein isolates like α-lactalbumin always have to separate lactose and casein and other fractions from whey which makes obtaining undentured proteins difficult as glutathione production in various tissues is restricted to the undenatured conforma­tion of whey protein. The word “denatured” is a biochemical process in which proteins lose their structure.

Lactose is a healthy sugar required by probiotics for energy. Casein is easily separated by straining yogurt.

Lactose is made up of glucose and galactose.

Lactose is a non fermentable sugar.

Galactose is actually an essential nutrient for the human body. It is a healthy disaccharide sugar.

Lactose does not cause intestinal necrosis (uncontrolled cell death) in premature infants.

Of the milk sugars, galactose, but not prebiotic galacto-oligosaccharide (GOS), improves insulin sensitivity. Intake of galacto-oligosaccharides (GOS) improved the gut microbial profile but did not improve insulin sensitivity.

Your Immune System Would Not Be Able To Function Without Galactose

Your body wouldn’t know which cells are “good” and what cells are “bad.” Your body wouldn’t know who the invaders were and which ones should be attacked by antibodies.

Only Whey Protein Or Diets That Contain This Protein Improve Antioxidant Function

If poor protein synthesis is your problem try acid or sour whey in small amounts at first and slowly increase. 1/8 – 1/4 cup makes a great addition to milk. Learn how to make superior bio active acid whey that is much more powerful than simply straining yogurt to obtain whey, made with a product that has increased lactic acid bacteria similar to that as found in the microbiota of breast fed infants here©.

Most people go quickly downhill because they don’t understand the importance of whole fat dairy mammal milk products as a bio active addition to their daily diet. The intestinal macrophage pool requires it for regeneration of particular stem cells in intestinal crypts which offer vital protection, including protection against radiation damage. It might interest you to know that in order to undo the restrictive blood brain barrier function in animals, they had to be exposed to radiation. Drink your milk, today’s research makes your local dairy farmer a very valuable addition to your life!

I say that gratefully with every step I take and I walk at least 45 minutes per day (stem cell migration from marrow requires movement and exercise).

In fact, now that it is back to school time, school cafeteria’s are eliminating daily juice in favor of milk and water only.

People might wonder why I routinely only write about certain ‘molecules’ it is quite simple, there are no bioactive substances on earth that can replicate them in their entirety and no synthetic to date has come close and aside from a very few exceptions they virtually can’t be mass produced as a ‘drug‘.

Abandonment of this highly conserved, localized natural mammalian process leads to generational decline and extinction.

August 21, 2018©

Whey Protein And Severe Brain Disorders©

Glutathione (GSH) is a primary endogenous antioxidant. GSH redox imbalance in brain disorders have been well studied and can be considered as a bio marker.  GSH depletion and GSH-related enzyme deficit are involved in the pathology of brain disorders such as autism, schizophrenia, bipolar disorder, Alzheimer’s disease, and Parkinson’s disease.

Humans with neurodegenerative and neuropsychiatric disorders have altered levels of GSH and oxidized glutathione (GSSG), decreased ratio of GSH/GSSG and impaired expressions of GSH-related enzymes in the blood or brain. GSH depletion can lead to abnormalities in methylation metabolism and mitochondrial function. Some studies have shown that a GSH deficit occurs prior to abnormalities in these diseases.

Tissue levels of various anti-oxidants such as vitamin E as a biomarker are not predictive or consistent but levels of GSH are consistent biomarkers in brain related diseases and consistently show age related decline in animals and humans.

Potential therapeutic agents for brain disorders include a whey protein, which can increase the GSH levels in the brain and alleviate oxidative stress-associated damage and may improve the behavior of individuals with brain diseases.

The amino acid cysteine in whey protein is a substrate for the synthesis of glutathione in the body.

GSH plays an important role during the onset and progression of neuropsychiatric and neurodegenerative diseases. GSH redox imbalance may be a primary cause of these brain disorders and may be used as a biomarker for diagnosis.  Agents that can increase the concentration of GSH in the brain are promising approaches for the treatment of these brain disorders.

Undenatured whey protein of bovine origin increases glutathione in various tissues.

Oral administration of substantive amounts of bovine whey protein enhances the glutathione content in the liver, heart and spleen. This change is moderate but sustained over time and biologically significant.

This property is restricted to the undenatured conforma­tion of whey protein.

  • The administration of glutathione itself is of little consequence on tissue glutathione levels, because it  cannot be transported intact across the cell membrane. Some methods of increasing intracellular levels of glutathione concentration are either toxic or dangerous due to the risks related to the initial phase of glutathione depletion. (Altered levels of GSH and oxidized glutathione (GSSG), decreased ratio of GSH/GSSG and impaired expressions of GSH-related enzymes in the blood or brain.)

Powdered Whey Protein supplements are not undenatured.

Activated microglia/macrophage whey acidic protein inhibits pro-inflammatory gene expression, reduces microglial neurotoxicity, promotes filopodia formation and increases phagocytic uptake of apoptotic debris.
Activated microglia/macrophage whey acidic protein triggers a neuro-protective phenotype in microglia and that whey acidic proteins may be potential therapeutics to inhibit a detrimental microglial phenotype in neurodegenerative diseases of the brain and retina.

Oleic Acid Is Necessary For Proper Brain Function

What is Oleic Acid?

  • One of the most common fats in human breast milk
  • Makes up 25% of fat in cow’s milk

Myelin is a protective covering or sheath that twists around nerves (neurons), including nerves in the brain. Myelin is made of 70% fat and 30% protein. Oleic acid is one of the most common fats in myelin.

Oleic acid doesn’t just help synthesize myelin, it is also a cell signaling molecule. Oleic acid regulates cholesterol and lipogenesis (making fat) in the brain. A  diet high in monounsaturated fats (including oleic acid) reduces age-related changes in the brain’s mitochondria.

Fatty acid composition in the postmortem amygdala of patients with schizophrenia, bipolar disorder, major depressive disorder, Alzheimer’s disease or mild cognitive impairment showed a mild to severe (up to 80%) decline of oleic acid concentration as compared to those with no cognitive impairment.

Tip:

Nearly all immune deficient people have tried powdered whey supplements, they can show benefit after months of use but they are not superior to home made products. Most powdered whey supplements use sweet whey as a byproduct of cheesemaking. Acid whey products are only now being introduced in to the marketplace as a byproduct of Greek Yogurt processing. Processing of whey to decrease denatured proteins requires advanced production methods. Sweet whey is a by-product of cheese production, while acid whey is a by-product of fermentation and acid coagulation of milk.

Only bovine colostrum processing ensures an intact bio supplement with little protein destruction.

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August 20, 2018©

A Whey Protein Diet Promotes Longevity©

Whey is a protein found in milk and dairy. It is a complete protein. It contains all the amino acids your body needs to function and build important body parts like liver cells and muscles.

Easily digested, acid whey and sweet whey are considered some of the best protein foods for human consumption.

Learn how to make Alternavita exclusive kefir strained acid whey recipe© here from a super easy homemade kefir that retains all probiotics and friendly yeasts.

A whey protein diet has been shown to promote longevity.

Although whey proteins increase adaptive and innate immune response, complete proteins enhance GSH more effectively than incomplete proteins.

Whey proteins are the group of milk proteins that remain soluble in “milk serum” or whey after precipitation of caseins. The major whey proteins in cow’s milk are beta-lactoglobulin (β-L), alpha-lactalbumin (α-L), immunoglobulin and serum albumin (SA).

Whey protein increased lymphocyte glutathione (GSH) in humans.

The actions of glutathione are particularly important in actively metabolising cells such as lymphocytes and adequate levels of glutathione have been shown to be necessary for lymphocyte proliferation in the development of the immune response.

Glutathione is the most abundant thiol in mammalian tissues and is not only central in cellular protection against oxygen radials, but also maintains normal tissue hydration, detoxifies a variety of compounds and xenobiotics and is important in the binding and elimination of transitional metals.

Modulation of intracellular glutathione affects the proliferative immune response of lymphocytes which may be inhibited by oxidative injury. Glutathione protect the cells against radiation and alkylating agents.
Age-related or experiment­ally induced glutathione depletion in the lens is associated with cataract formation.
Oxidative DNA damage is rapidly and effectively repaired. The human body is continually repairing oxidized DNA. A small fraction of unrepaired lesions, however, could cause permanent changes in DNA and might be a major contributor to old age diseases and cancer.
Several age associated diseases may be induced by free radicals. It appears that data on age-related changes in tissue vitamin E and other antioxidants are contradictory. Glutathione levels are more consistently reported to decline with old age in animals and man.
  • The administration of glutathione itself is of little consequence on tissue glutathione levels, because it  cannot be transported intact across the cell membrane. Some methods of increasing intracellular levels of glutathione concentration are either toxic or dangerous owing to the risks related to the initial phase of glutathione depletion.

Undenatured whey protein of bovine origin increases glutathione in various tissues.

Acute inflammation is an obligatory innate response of the host to an infectious and noninfectious injury. The physiological endpoint of such an inflammatory response is helping eradicate the agent(s) of the injury and restore homeostasis. Inflammatory response can be favorably enhanced by priming agents. These agents can increase neutrophil primary functions associated with innate immunity such as adherence and migration, phagocytosis.  Whey protein can be considered as a complete priming agent that enhances primary functions of normal human blood neutrophils. As a corollary, whey protein can be easily compared with known priming agents that activate the translocation to plasma membrane of neutrophils. This priming effect of whey protein could be efficient in vivo. Whey protein ingested orally by patients has an anti-inflammatory capacity without any side effects.

Whey Protein Can Enhance Innate Immunity by Priming Normal Human Blood Neutrophils

Bovine whey reduces apoptosis of human blood neutrophils and exerts a dose-dependent priming effect on these cells that, when stimulated subsequently, have increased functions of adherence, chemotaxis, phagocytosis, oxidative burst, and degranulation.

The major whey protein components β-lactoglobulin (β-LG) and α-lactalbumin (α-LA) were the main active fractions having an additive effect on human neutrophils that became more responsive to a subsequent stimulation. This effect on oxidase activity was associated with translocation to plasma membrane. Glycomacropeptide, a peptide present in measurable amounts in whey protein products, was able to enhance the individual effect of β-LG or α-LA on neutrophils. Whey protein through β-LG and α-LA, has the capacity to enhance or “prime” human neutrophil responses an effect that is associated with increased innate defenses.

AlphaLactalbumin is the major protein in breast milk (20-25% of total protein) and has been described to have several physiologic functions in the neonatal period. αLactalbumin facilitates the absorption of essential minerals and is crucial for protein synthesis of the developing neonate.

Oral administration of substantive amounts of bovine whey protein enhances the glutathione content in the liver, heart and spleen. This change is moderate but sustained over time and biologically significant.

This property is restricted to the undenatured conforma­tion of whey protein.

The word “denatured” is a biochemical process in which proteins lose their structure.

Glutathione is a tripeptide. The administration of either cysteine or glutathione itself or other protein sources such as egg white are ineffective in raising cellular levels of GSH.

The addition of whey protein to the diet of healthy and diseased humans could be useful to increase the physiological innate response of their neutrophils.

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This blog electronically shreds all emails, contact info, posts and post data etc. after 30 days. I don’t mind if you write but don’t expect any of your info to be saved for the sake of your privacy and security.

August 2018: My personal email is no longer a valid contact.

August 18, 2018©

Feed The Good Bacteria In The Colon

Cutting out dairy can make you lactose intolerant.

“The bacteria in our colon need to be fed in order to survive,” Dennis Savaiano, PhD, Meredith Professor of Nutrition Policy at Purdue University “So whatever you feed them, those bacteria are going to prosper.

“Individuals who are used to eating lactose in their diet have more lactase enzyme [than people don’t eat lactose-containing foods]—we think six to eight times more—and are more efficient at digesting it so they don’t get symptoms.”

Lactase is a necessary enzyme for macrophage activation.

Lactase deficiency is immune deficiency

It has been shown that severely ill diabetic patients have a decreased amount of galactose and sialic acid on their buccal cells, compared with minimally ill patients and healthy controls.

Lactose is made up of glucose and galactose.

Lactose is a non fermentable sugar.

Galactose is actually an essential nutrient for the human body. It is a healthy disaccharide sugar.

Lactose does not cause intestinal necrosis (uncontrolled cell death) in premature infants.

Of the milk sugars, galactose, but not prebiotic galacto-oligosaccharide (GOS), improves insulin sensitivity. Intake of galacto-oligosaccharides (GOS) improved the gut microbial profile but did not improve insulin sensitivity.

Your Immune System Would Not Be Able To Function Without Galactose

Your body wouldn’t know which cells are “good” and what cells are “bad.” Your body wouldn’t know who the invaders were and which ones should be attacked by antibodies.

Galactose As New Immune Response Treatment Replacing Dangerous Synthetic IVIG For Lupus Treatment

Without gcmaf research and the work of Dr. Nobutu Yamamoto and many others these effective state of the art immune therapies would not be available today.

β-galactosidase, also called lactase is important for organisms as a key provider in the production of energy and a source of carbons through the break down of lactose to galactose and glucose. It is also important for the lactose intolerant as many adult humans lack the lactase enzyme, which has the same function of beta-gal, so they are not able to properly digest dairy products.

Kefir grains show β-galactosidase enzyme activity, which stays active when consumed. β galactosidase enzymes found in kefir and yogurt are able to convert gc globulin protein to macrophage activating factors during the fermentation process. β-Galactosidase treatment is a common first-stage modification of the three major subtypes of Gc protein to GcMAF (a popular and effective immune therapy treatment).

You can actually retrain your body to break down lactose efficiently.

The trick is to start with small amounts of lactose and gradually build up the amount you’re consuming and pairing high-lactose foods with other foods so as not to overload your digestive system.

Yogurt and kefir contain much less lactose than milk but acid whey strained from yogurt to make Greek Yogurt has higher amounts of lactose and much less casein.

Acid whey contains more than twice the amount of galactose as ‘sweet’ or ‘cheese whey’.

Read more about the beneficial effects of dairy products and how and why they have been developed as important natural immune therapeutics here.

Tip:

Most people forget that dairy and especially lactose = galactose is a daily requirement for life and even after much improvement on natural immune therapy they begin to slack off on this important daily requirement. The intestinal macrophage pool requires constant regeneration unlike other stem cells or the digestion of cellular debris (phagocytosis) will not occur leading to endotoxemia and oxidative stress. Milk increases phagocytosis, especially in the elderly.

Whey Protein From Dairy Products

Only Whey Protein Or Diets That Contain This Protein Improve Antioxidant Function

Several studies also shown in different models of oxidative stress that only whey protein or diets that contain this protein improve antioxidant function and decrease oxidative stress as compared to consumption of other proteins.

Look for whole fat mammal milk and whole fat yogurt which contains 25% oleic acid. It does not have to be organic or raw milk, organic milk has decreased immune benefit due to differential processing requirements as does UHT milk.

Regular whole fat mammal milk utilized as a substrate for Bravo Yogurt™ production, any yogurt production, kefir production, cheese making, strained acid/sour whey collecting does not have any reduced factors such as lactose, fat, sulfate etc. It is fine for natural immune therapeutic purposes. All mammal milk has to be heated pre-yogurt making and then cooled to reduce unwanted contamination risk and to ensure only beneficial microbes repopulate.

Pasteurizing milk does not destroy important immune factors. All health benefits can be found in regular whole fat mammal milk. Acid whey collected from strained yogurt as a byproduct of Greek Yogurt production is not the same as powdered whey supplements as used by body builders, bodybuilding powders are  processed in such a way that destroy some important benefits.

Most body building supplements and fillers in food products like ice cream and infant formula are obtained from sweet whey as a byproduct of cheese production. Acid whey products are slowly being introduced in to the marketplace as energy drinks due to the popularity of Greek Yogurt and increased abundance of this byproduct but use is not widespread.

The greatest benefit bio active whey substances can easily be obtained by home processing yogurt or kefir, learn how here©.

Both acid whey and sweet whey are beneficial, as obtained from cheesemaking and yogurt processing; ALL dairy products have great health benefits.

The functional food market is an expanding market to reduce overall food waste and an attempt to make processed food healthier by utilizing byproducts. Expect marketing claims that attempt to commercialize each byproduct in order to increase sales. Whey is slightly different depending upon source but all dairy products including milk are beneficial.

Only bovine colostrum is a unique supplement processed in such a way as to retain all components of the natural living source bio active product.

Bovine colostrum is processed in such a way because it can not be sold as a non bioactive substance as it is used as a replacement feeding in mammals that require it for survival and can not obtain it from their mother. Bovine colostrum is considered a near universal donor, a few animal species better tolerate colostrum other than bovine. Humans are not one of them. Bovine colostrum is the source of gcmaf health products and other immune therapeutics not obtained from blood.

 

August 17, 2018©

Acid Whey For Gut Health, Mental Health And Quickly Fighting Obesity

50% of Americans are trying to lose weight. Too many Americans take anti depressants (an unsafe, mental health and physical health killer).

Acid whey quickly helps overcome a bad diet, a pot belly and a bad mood.

In a study rats who consumed plain white bread (store bought plain white bread, a killer) or bread made with 20% whey had better digestion in the small intestine, including increase of good bacteria (bifido) and higher production of short chain fatty acids by bacteria. The rats who ate the whey bread also gained less weight than the rats who ate plain bread.

Whey protein reduces metabolic syndrome and cardiometabolic risk factors

Consuming more dairy foods protects you from developing metabolic syndrome.

Whey protein addresses several symptoms of metabolic disorder. It combats type 2 diabetes by improving insulin response and normalizing glucose levels. Eat over 10 grams of whey protein a day for the best effects.

Whey reduces cardiovascular risk factors by promoting blood pressure reduction and decreasing arterial stiffness.

Consuming whey can reduce central obesity and increase lean body mass, especially when taken in conjunction with exercise, whey can quickly eliminate a pot belly.

Whey protein enhances mood

Stressed out people who consumed alpha-lactalbumin, a protein found in whey, reported feeling less depressed and had better coping skills. They also had increased prolactin concentrations and decreased cortisol concentrations.

Consumption of alpha-lactalbumin increased people’s ratio of plasma tryptophan when compared to other large neutral amino acids (Trp-LNAA ratio). This increases tryptophan availability and may increase serotonin concentrations. Serotonin elevates mood and promotes feelings of calmness. Alpha-lactalbumin elevates mood and enhances sleep.

* Bovine colostrum will reset circadian rhythm almost immediately, for night owls or shift workers. Sleep is essential for detoxification, especially brain detoxification. The brain/lymphatic system does not work properly without sleep, in fact it doesn’t work at all, it only works DURING sleep. The right fats only enhance this mechanism but do not replace it.

Whole Fat Mammal Milk

Those who consume whole fat dairy products lose more weight than those who consume low fat versions.

Milk fat contains 25% oleic acid. Oleic acid is an monounsaturated omega-9 fatty acid with many health benefits.

It is recommended to take a tsp. of olive oil (high in oleic acid) with MAF yogurts.

Higher Brain Levels of Oleic Acid Associated with Plasticity (Extraversion and Openness) in Boys with ADHD

Researchers looked at the connection between concentrations of blood fats in the brain and personality traits in adolescent boys with attention deficit hyperactivity disorder. Boys with a higher concentration of oleic acid had more traits associated with plasticity, a positive personality trait associated with extraversion (positive emotion, enthusiasm, sociability, assertiveness) and openness (imagination, intelligence, curiosity, creativity).

A recent study found a 6.2% decline in oleic acid in the postmortem brains of patients who had been suffering from major depressive disorder when compared to a normal brain. Likewise, postmortem brain plasma from people with Alzheimer’s disease or mild cognitive impairment had a 80% and 70%, respectively, lower oleic acid concentration than those with no cognitive impairment.

Oleic acid is necessary for proper brain function

Oleic acid accounts for 50% of fatty acids in humans, oleic acid is the natural state of healthy fat balance

Most of fatty acids bound to human and bovine DBP (Vitamin D Binding Protein or GC Globulin) are monounsaturated and saturated, mainly oleic and palmitic acids, which together account for 50% of the total of fatty acids in both species. By contrast, polyunsaturated fatty acids represented a minor component, less than 5%.

Tip:

We always make our bread and rolls at home using strained acid whey to replace part of the liquid in bread recipes. Store bought white bread is not healthy for far too many reasons to list here but it would be better to visit the fresh bakery in the store as opposed to factory produced bread if baking bread at home is not an option.

I don’t avoid bread, I avoid unhealthy, processed, store bought, factory made bread and cereals.

Kwashiorkor (PCM Protein Calorie Malnutrition) began in African children after beginning consumption of cereals. American children go from bottle feeding to cereal to juice and consume practically zero amounts of food in their natural states. Read more  about how inherent worldwide malnutrition syndromes begin here.

These forms of inherent chronic malnutrition syndromes, Kwashiorkor, Marasmus and Marasmic Kwashiorkor are not reversed with diet but are dysbiotic microbiota associated as a causal factor. 

It is a sad fact that by 2005, 90% of US children were not breastfed or sub-optimally breast fed, in some countries in the America’s 50% of children are routinely born via C section. These widespread practices alone lead to immune tolerance, dysbiosis and SIBO formerly inherent predominately in industrialized countries with various and numerous negative health consequences like obesity and mental health issues that are generationally compounded in a negative health cycle if not reversed in hospital birth settings. All mammals require colostrum and tolerance is built upon later lactation mammal milk.

ALL diet advice in books, medical institutions and on the internet avoid discussion of root causes, none express basic moderation and virtually none delve in to mass food production, diet and farming history. And no one advises mother’s on the dire consequences of not breast feeding making bottle vs. breast a personal choice or preference which is frankly ludicrous as no farmer or vet would even advise that for the health and benefit of an animal as they understand it is crucial and a situation to be avoided at all costs. It is but one good reason to avoid the mainstream diet advice rat race. And I am sorry to say the nations who are the leaders in today’s natural immune therapeutics like gcmaf were historically among the first and worst offenders as early proponents and mass marketers of infant formula long before the practice reached the western nations on a wide scale.

Making bread at home is easy and it does not take a lot of time, in fact most consumers don’t even know at one time we didn’t even have yeast in cakes or packets but yeast spores were naturally collected from the surrounding air to raise bread dough.

I personally avoid bread in restaurants if it is not fresh baked. Fast food restaurants especially, as they use cheaper ingredients and too many preservatives to help keep costs low. This is one reason we have so much acid whey to consume as we also make our own kefir and yogurt and use the cream cheese like product after straining for use in desserts as well.

Acid whey enhances nutritional benefit and is suited to a better baking process as compared to just using water. We have found many ways to use liquid whey and have increased our daily nutrition in vitamins and minerals as well as increasing immune and metabolic benefits as liquid whey is a bio concentrated and bio active functional food. Liquid whey along with whole fat mammal milk also helps maintain a healthy gut and immune system.

And remember….

Only Whey Protein Or Diets That Contain This Protein Improve Antioxidant Function

Several studies also shown in different models of oxidative stress that only whey protein or diets that contain this protein improve antioxidant function and decrease oxidative stress as compared to consumption of other proteins.

August 16, 2018©

Natural Immune Benefits In Whey

Whey protein contains about 10-15% immunoglobulins.

Milk immunity research helped develop the basic principles of modern immunology.

Four classes of immunoglobulins are present in whey serum: IgG, IgA, IgM, and IgE.

IgM is in the first line of immune system defense. These large antibodies can attack many types of intruders. IgM antibodies are released when an organism is exposed to an antigen for the first time. These ‘first responders’ also recruit other immune cells to attack dangerous microbes.

IgA are common antibodies in mucosal areas such as the nose, lungs, eyes and ears. They prevent mucosal infections by causing microbes to agglutinate (clump). In the intestine, IgA is an immunosuppressant that inhibits proinflammatory responses to oral antigens. IgA deficiency is common and is associated with many conditions including SIBO.

IgG is the primary immunoglobulin present in cow’s milk and whey. This is also the most common type of human antibody and makes up about 75-80% of the antibody population. Once in the intestine, IgG antibodies inactivate harmful infectious organisms by binding to them. This reduces or eliminates microbes’ ability to cause illness.

Selective immunoglobulin M (SIgM) deficiency occurs when people don’t make enough IgM. People with SIgM can be extremely susceptible to viruses, bacteria and fungus. Some people with this disorder develop dangerous infections that can be life threatening. They also have a tendency to develop autoimmune disorders.

Alpha-lactalbumin

How does whey protein enhance GSH? Alpha-lactalbumin, a whey protein, contains high levels of cysteine, an amino acid used to make glutathione.

Why do we want GSH?

GSH is an extremely powerful internal antioxidant that enhances health in numerous ways.

Alpha-lactalbumin is a bioactive milk protein found in acid whey. Whey protein typically contains 20-25% α-LA. This is the same amount found in human breast milk. In babies, it protect against infection and may indirectly increase mineral absorption in the gut by promoting the growth of essential gut microorganisms (2018).

When α-LA is broken down (hydrolyzed) by the body it releases cysteine. Cysteine is a precursor to glutathione (GSH), a vital internal antioxidant. Alpha-lactalbumin has a direct effect on the body. It increases production of serotonin and glutathione. Alpha-lactalbumin increases liver glutathione after strenuous exercise.

Whey protein increased lymphocyte glutathione (GSH) in humans. Overweight young men who exercised and consumed whey protein isolate had a significant increase in GSH and total antioxidant capacity compared to the control. Resistance exercise combined with whey protein produced more cardiovascular and antioxidant benefits than exercise alone. Another study found that people consuming 45 grams of whey protein over 2 weeks had a 24% increase in GSH.

Whey protein enhances GSH concentration and promotes longevity. Whey protein enhances GSH production while promoting wound healing.

Alpha-lactalbumin inhibits human colon cancer cells, human breast cancer cells and colon carcinogenesis.

Oleic acid is a monounsaturated fatty acid also found in milk. It binds to milk proteins, such as α-lactalbumin and lactoferrin, to form potent complexes. These compounds have selective anti-tumor activity against malignant cancerous cells, including Caco-2, HepG-2, PC-3, and MCF-7 tumor cells, but are nontoxic for normal cells (2018).

Stressed out people who consumed alpha-lactalbumin had increased prolactin concentrations and decreased cortisol concentrations.

Whey And Allergies

According to several large review papers, whey protein reduces the risk of cow’s milk allergy and atopic dermatitis in susceptible children and infants.

Whey proteins found in both human and cow milk stops the inflammation process to help protect infants against gut inflammatory disorders. Lactoferrin present in human and cow milk is digested by stomach pepsin. This releases lactoferricin, a powerful antibiotic that neutralizes bacteria, fungus, viruses and parasites. Lactoferricin promotes a healthy digestive tract by protecting beneficial intestinal microflora. Lactoferrin given orally may protect infants from necrotizing enterocolitis, a dangerous disease.

Whey protein improves psoriasis

Psoriasis vulgaris (PV) means “itching condition”. People afflicted by this chronic autoimmune disease have red itchy patches that may be covered with silvery white scaly plaques or pustular spots. These painful itching spots can cover skin, nails and internal organs. Psoriasis vulgaris may be activated by stress or illness. People with PV have systematic inflammation, high oxidative stress and low glutathione concentrations.

In a very small trial, seven patients received 20 grams of whey protein in addition to their current treatments. All the patients showed significant improvement in their PV symptoms, including those who were only taking the whey protein.

Whey protein may help heal psoriasis patients by relieving oxidative stress.

 

August 15, 2018©

Protein Vs. Protein – Forget Paleo And Opt For Functional Proteins

The majority of store bought, processed foods contribute nothing to health and are actually detrimental to health. Synthetic vitamins are not equal to vitamins obtained from whole food and beneficial probiotics. Organic foods offer little increased benefit and organic milk is little more than expensive white water. Don’t be fooled by advertising but learn the effects of processing on foods and for that you have to investigate industrial mass production methods, including effects to maintain freshness during shipping and to facilitate long shelf life. Very little on store shelves is equivalent to home production including bread and other products produced from grains. It takes a lot more work to obtain proper nutrition but the health benefits gained are far superior. Severely  limit junk food, fast food and processed food consumption.

The liquid whey you obtain at home is far superior as a functional food as compared to powdered and processed whey. Don’t even think the immense benefits can be replicated in any processed whey like whey products sold as body building supplements.

Only Whey Protein Or Diets That Contain This Protein Improve Antioxidant Function

Several studies also shown in different models of oxidative stress that only whey protein or diets that contain this protein improve antioxidant function and decrease oxidative stress as compared to consumption of other proteins.

Sweet whey is a by-product of cheese production, while acid whey is a by-product of fermentation and acid coagulation of milk, for example, the production of cottage cheese and recently popular Greek yoghurt.

Acid Whey As A Source Of Functional Proteins

Acid whey contains between 11 and 14% proteins, 60-70% lactose, 0.5-1.5% fats, and 9-12% mineral content. Among the proteins, functionally and nutritionally relevant fractions are represented, such as -lactalbumin (-La), β-lactoglobulin (β-Lg), bovine serum albumin BSA, lactoferrin (LF), lactoperoxidase (LP) and immunoglobulins (Ig). Sweet whey also contains glycomacropeptide (GMP).

Important whey functional proteins represent LF, LPO and Ig. These proteins conserve biological activity after ingestion and are not degraded and absorbed as amino acids in the small intestine. For example, LF is a glycoprotein with the ability to bind iron. It exhibits antimicrobial and anti-inflammatory activity and therefore plays a major role in strengthening the immune system. It is used in dietary supplements and baby milk blends. LPO is an antimicrobial glycoprotein. It causes damage to membranes of streptococci with oxidation reactions and thus their lysis. It is used in food products. Immunoglobulins are a sophisticated group of monomeric and polymeric glycoproteins (IgG, IgA, IgM). Because of their properties of strengthening immune resistance, they are used in nutritional formulas.

Whey proteins are easier to digest than casein. Immunoglobulin and other glycoprotein’s (lactoferrin, transferrin) and enzymes (lysozyme, lactoperoxidase) are very important factors that contribute to human immunoactive system. They exert antimicrobial properties, and may reduce or inhibit allergic reactions.

The largest constituent of whey is lactose. Most milk carbohydrates pass into the whey after cheese making of which 90% is lactose including some glucose, galactose, oligosaccharides and amino sugars. Lactose is a very important source of energy, and has multiple roles.

Some of the beneficial effects of lactose are:

  • Stimulation of intestinal peristalsis, facilitate calcium and phosphorus absorption.
  • Establishment of a mildly acid reaction in the intestines and prevents the growth and multiplication of harmful bacteria.
  • Ensures optimal magnesium levels and improves digestion of fat and other nutrients in the human body.
  • Lactose is a non-fermentable sugar so is not cariogenic and is not harmful to teeth. Milk and the associated dairy foods also tend to be high in protein, calcium and phosphates which help neutralise the effects of acid production which is beneficial to oral health.
  • Growth promoters of the bifidobacteria.

During the manufacture of cheese or casein some water-soluble vitamins permeate from milk into the whey. The most important of these vitamins are riboflavin, folic acid and cobalamine. Folic acid and cobalamine are bonded to whey proteins. Whey contains higher amounts of vitamin B2 than milk due to the activity of some starter cultures (i.e. lactic acid bacteria – LAB). Due to relatively high levels of riboflavin, whey has a characteristic yellowish-green color.

Tip:

Colostrum is king, milk is queen, beneficial microbes are heirs but liquid whey is nutritious and delicious for continued intestinal, liver and immune health.

  • It will reduce bloating and gas pronto
  • It favorably affects blood sugar levels
  • It creates energy
  • It quickly contributes to increased beneficial microbe populations
  • It is the best inflammation fighter and exceeds citrus as a detox helper as it greatly increases glutathione production
  • It (and whole fat mammal milk) helps facilitate faster weight loss
  • It is absorbed super fast so is nutritionally beneficial for those who have digestive issues

To learn how colostrum, milk, probiotics and kefir greatly benefit the majority of health conditions read more here.

After natural oral immune therapy treatment, liquid whey and milk may be all you need to maintain digestive health.

August 14, 2018©

Cardiovascular Disease Is Responsible For 30% Of Deaths Worldwide

Despite the cholesterol-lowering ability of certain pharmacological agents, unwanted direct effects can occur, such as gastrointestinal discomfort.

Statins have multiple confirmed negative effects including brain dysfunction.

Probiotic strains of lactic acid bacteria are better candidates for reducing the risk of cardiovascular and liver disease.

When L. lactis ssp. lactis is added to milk, the bacterium uses enzymes to produce energy molecules (ATP), from lactose. The byproduct of ATP energy production is lactic acid.

  • Lactic acid bacteria maintains normal insulin levels in the blood.

  • Lactic acid bacteria protects the liver.

Live lactic acid bacteria intake through dairy products have myriad beneficial effects on gastrointestinal tract of human beings ranging from correction of lactose malabsorption and maintenance of normal insulin level in blood.

Lactic acid bacteria are also helpful to enhance the absorption of fatty acids through intestine and reducing cholesterol, both in the liver and the serum.

Glutathione (GSH), an antioxidant tripeptide, is ubiquitous in eukaryotic system, found widely in Gram negative bacteria but was known to be scarcely present in Gram positive bacteria.

New insights into glutathione synthesis and metabolism in the LAB has mandated the requirement of putting extensive scientific efforts to understand its current status and emerging role in this functionally important group of Gram positive bacteria. Glutathione has diverse roles in biological systems for its antioxidative, immune boosting and cellular detoxifying activities. It helps to maintain the intracellular redox homeostasis to protect the cells against oxidative damage.

Glutathione is considered as one of the important molecules in oxidative stress protection.

This major property of glutathione has also now been proved in LAB (lactic acid bacteria).

Researchers in the 1970’s believed that lactic acid buildup caused acidosis (acid build up in the muscles) which resulted in muscle fatigue and caused soreness.

This myth is still prevalent today.

Now we know these beliefs to be false.

In a living system lactic acid is formed when glucose is burned anaerobically for fuel. The body uses lactic acid as a superfuel to help bridge the gap between anaerobic and aerobic respiration. Muscles can use lactic acid directly for energy. Any unused lactic acid is shuttled to other areas such as the heart or liver to be used as fuel (oxidized) or converted into glucose. In the 1970’s research on severed frog legs, lactic acid built up because it had nowhere to go.

In a dynamic living system, muscles, livers, heart or brain can use lactic acid.

Not only doesn’t lactic acid cause muscle soreness, but lactic acid actually prevents muscle fatigue!

D-lactic acidosis is a different problem not caused by L-lactic acid.

Tip:

Buttermilk is a superior anti-oxidant for blood pressure benefit. Kefir which has greater numbers of LABS than yogurt is also beneficial, however the fastest benefit can be seen in acid liquid whey derived from kefir made yogurt due to casein extraction leaving the majority soluble whey proteins and greater numbers of fermentable LABS, friendly yeasts and lactose. Learn how to make kefir acid whey here. To learn more about whey benefits see here.

Whey proteins have a compact globular structure that accounts for their solubility (unlike caseins that exist as a micellar suspension, with a relatively uniform distribution of non-polar, polar and charged groups). Whey proteins have amino acid profiles quite different from caseins.

Nutritionally whey proteins fractions are most valuable proteins because they contain high concentration of essential amino acids (especially lysine, cysteine and methionine) and high concentration of cysteine.

Because of the desirable amino acid composition, whey proteins have higher biological value when compared to casein, and other proteins of animal origin, including egg, which were considered for a long time as a referent proteins.

Daily requirements for the most essential amino acids may be obtained by consuming 1.5 L (nearly 50 oz.) of whey or 0.5 L (16 oz., two glasses) of milk.

The protein content in acid and sweet whey is very similar; however, the amount of free amino acids can vary and depends on a degree of casein hydrolysis during the manufacture of cheese (acid or sweet). Thus, the amount of free amino acids in sweet whey is about 4 times higher, and in acid whey even 10 times higher than in milk. This means the amino acids in whey are readily absorbed as compared to milk.

1.5 liters of liquid whey may be too much to try to obtain amino acid benefit as compared to drinking just two glasses of milk. Add liquid whey in the desired amount to milk (1/8-1/4 cup) for free amino acids and other important benefits such as bio-acive peptides and other important proteins but some diets like GAPS do recommend more.

Whey contains a pool of bioactive peptides. Bioactive peptides are specific protein fragments that have a positive impact on body functions or conditions and may ultimately influence health. Upon oral administration, bioactive peptides, may affect the major body systems—namely, the cardiovascular, digestive, immune and nervous systems.

The beneficial health effects may be classified as antimicrobial, antioxidative, antithrombotic, antihypertensive, antimicrobial or immunomodulatory.

 

August 11, 2018©

Tip:

Probiotic Capsules Without Milk Are Virtually Useless

It is generally assumed that most readers always consume probiotics with milk or if not utilize fermented products kefir, yogurt, cottage cheese, buttermilk etc. that are the byproduct of milk fermentation but it is worth repeating…..

Without milk, probiotic capsules do virtually nothing but contribute to bacterial overgrowth especially in the presence of excess undigested carbs (even the friendliest colonizers). Some probiotics and friendly yeasts are capable of utilizing other sugars for fermentation but milk oligosaccharides are the ideal substrate for most friendly organisms that contribute directly to their immune effects, in fact milk oligosaccharides are the reason for their epigenetic modulation.

Do not take more than the recommended dose of any probiotic and always take with milk (milk increases phagocytosis, especially in the elderly).

Homemade kefir and yogurt have trillions of friendly organisms but do not generally cause the same bacterial overgrowth problems as probiotic capsules do in the absence of other major contributing factors such as drug overuse (PPI’s, opioids, steroids, etc).

Bacteria, fungi, and actinomycetes release hydrogen sulfide during the decomposition of sulfur-containing proteins and by the direct reduction of sulfate (SO4 2-).

Probiotic capsules contribute to bacterial overgrowth in the colon in the presence of excess undigested carbohydrates. This may lead to D-lactic acidosis, a common co-condition associated with short bowel syndrome, gastric bypass and is implicated in other disorders such as chronic fatigue syndrome. Humans are poor metabolizers of D-lactic acid.

L plantarum has been clinically shown to reverse D-lactic acidosis.

D-lactic acidosis contributes greatly to brain fog and other neurologic symptoms like irritability, memory loss and various encephalopathies. SIBO produces mild, chronic encephalopathy. SIBO recipe also helps reduce D-lactic acidosis. D-lactic acidosis is also associated with chronic malnutrition disorders, especially lack of B vitamins.

Stop taking probiotic capsules without milk to avoid such problems like D-lactic acidosis and bacterial overgrowth. Restrict excess carbohydrates until the problem diminishes. Ensure food is well cooked to avoid hard to digest fiber. If you have problems like bloating that persist (some initial bloating is normal) with probiotic capsules don’t blame the probiotics themselves as many external factors contribute to excess bloating, bacterial overgrowth and D-lactic acidosis. Friendly yeasts like Kluyveromyces marxianus are capable of utilizing many sugars for energy. Stick to well tolerated in the majority, clinically studied and GRAS probiotics and don’t introduce too many types of organisms at once if immune tolerance is present, treat yourself like a baby if you have severe gut disorders and always know exactly what species you are introducing until digestion is fully restored (just like a newborn who has to introduce things slowly).

Take colostrum, olive oil and whole fat mammal milk only in small amounts if probiotic capsules cause persistent bloating. It will shift the microbiota to a more favorable population in a very short time. Or just use acid whey and milk or water. Bloating actually does not usually occur with kefir so I would suggest looking for another cause like other undigested food or hard to digest fibers or as research suggests, undigested carbohydrates (some pre-biotics, starches and sugars that are popular that do not digest like inulin etc.). Food must be well cooked so tough fibers can be broken down. And don’t take too many probiotics that are prolific colonizers, some probiotics are not. When you have yogurt, kefir, colostrum and milk probiotic capsules are not really necessary after some initial replacement to recover from some known microbiota loss like antibiotic use and even then stick to research recommended replacement after antibiotic use and don’t rely on marketing claims in a highly unregulated alternative market. Probiotics should not be allowed to be patented. It violates the principle of prohibition of claiming ownership of a natural substance. In other words, buyer beware, the probiotic market is often a racket even when based on much inherent truth.

As long as your gut is not sterile and if it was you’d likely be dead, you can favorably shift microbiota populations using functional food products like yogurt, kefir and dairy so most supplements are a waste of time and money.

Such a striking difference could be explained considering that during the fermentation of milk by the probiotic strains that compose a yogurt, several newly formed peptides are generated and it is likely that the overall immune-reconstituting effect is due to a combination of microbes and the products of their metabolism rather than to the microbes alone (Ebner et al., 2015). Consistent with this interpretation, the Authors concluded that: “The inefficacy of the probiotic strains in preserving the immune function may be the result of using encapsulated probiotics versus the use of probiotic yogurt with the same probiotic strains in previous studies …” (Hummelen et al., 2011). ….milk and colostrum as media for fermentation…. Macrophages of the mucosa-associated lymphoid tissue (MALT) as key elements of the immune response to vitamin D binding protein-macrophage activating factor. Encapsulated probiotics however proved ineffective at preserving immune  function lending credit to the theory that other factors may be required to restore full immune function. Endogenous production of natural gcmaf by bacteria that produce enzymes that convert milk gc protein into active gcmaf an event that can not occur if the same bacteria are administered as encapsulated probiotics.

August 10, 2018©

Acid Whey Reverses Neurodegenerative And Retina Inflammation By Activating CNS Macrophages 

Whey is the liquid remaining after milk has been curdled and strained. It is a byproduct of the manufacture of cheese or casein and has several commercial uses. Sweet whey is a byproduct produced during the manufacture of rennet types of hard cheese, like Cheddar or Swiss cheese. Acid whey (also known as sour whey) is a byproduct produced during the making of acid types of dairy products, such as cottage cheese or strained yogurt. Liquid whey is the yellowish, green liquid you often see floating on top of unstirred yogurt, sour cream or cottage cheese. All mammal milk products contain whey but all whey is not identical.

Microglial cells are the resident macrophages of the central nervous system (CNS), including the retina, and play a pivotal role in innate immune responses and regulation of homeostasis in the healthy and degenerating CNS.
Despite being cells of the mononuclear phagocyte lineage, their CNS-specific location and morphology clearly distinguishes them from other macrophage populations.
Microglial cells, the resident phagocyte population of the nervous system, exert several important functions in immune surveillance and neuronal homeostasis. In the healthy brain and the retina, ramified microglia serve as highly motile patrolling cells constantly surveying their microenvironment.
Reactive microgliosis is a common indicator of various neurodegenerative syndromes
Reactive microgliosis is a common indicator of various neurodegenerative syndromes including Alzheimers disease, Parkinsons disease, multiple sclerosis, inherited retinal degenerations and several other retinal conditions.
Whey acidic protein family is characterized by a highly conserved whey acidic protein domain which is
named after the most abundantly expressed protein WAP. Activated microglia/macrophage whey acidic protein is closely related to secretory leukocyte protease inhibitor (SLPI), which is the best studied whey acidic protein. In contrast to activated microglia/macrophage whey acidic protein, SLPI is produced at mucosal surfaces as well as by neutrophils and macrophages. SLPI was recently identified as a biomarker for amyotrophic lateral sclerosis and its application has beneficial therapeutic effects after spinal cord injury and optic nerve damage.

Toll Like Receptor (TLR)-mediated NFκB signaling is a major pathway of pro-inflammatory microglia reactivity that may contribute to chronic neuro-inflammation. Whey acidic proteins inhibit NFκB activation in monocytes. TLR2 and TLR4 acts on the cell surface and predominantly signals via NFκB. 

Activated microglia/macrophage whey acidic protein is a secreted protein of reactive microglia that acts in a paracrine fashion to prevent TLR4 and TLR2 triggered NFκB translocation. 

Activated microglia/macrophage whey acidic protein significantly inhibited the LPS (e coli)-triggered release of nitric oxide from microglia. Activated microglia/macrophage whey acidic protein also reduced microglial neurotoxicity on photo receptor cells and similar to secretory leukocyte protease inhibitor (SLPI) has been shown to reduce LPS-induced neutrophil apoptosis. A lack of secretory leukocyte protease inhibitor (SLPI) resulted in increased apoptosis of myeloid cells.

Apoptotic cells represent an activating stimulus for microglia independent of LPS stimulation

Filopodia formation is a hallmark of homeostatic microglial cells that constantly survey their microenvir-
onment with their branched protrusions. Activated microglia/macrophage whey acidic protein promotes the formation of branched filopodia. High phagocytic clearance of apoptotic debris by microglia is also regarded as an important anti-inflammatory feature. Activated microglia/macrophage whey acidic protein  increased phagocytic uptake of apoptotic photoreceptor fragments by treated microglia which was independent of further LPS stimulation as apoptotic cells (cellular debris) represent an activating stimulus for microglia.
Activated microglia/macrophage whey acidic protein inhibits pro-inflammatory gene expression, reduces microglial neurotoxicity, promotes filopodia formation and increases phagocytic uptake of apoptotic debris.
Activated microglia/macrophage whey acidic protein triggers a neuro-protective phenotype in microglia and that whey acidic proteins may be potential therapeutics to inhibit a detrimental microglial phenotype in neurodegenerative diseases of the brain and retina.
*The whey acidic protein family used in this research is characterized by a highly conserved whey acidic protein domain which is named after the most abundantly expressed protein WAP from rodent milk.

No, you don’t need rodent mammal milk to achieve the same benefits as can be found in mammal milk.

Apoptosis is death of cells that occurs as a normal and controlled part of an organism’s growth or development. Necrosis is uncontrolled cell death.

Tip:

Yogurt, kefir, buttermilk, real cottage cheese, farmer’s cheese, quark or liquid whey and milk are daily requirements for life!

These you can never stop even after colostrum, gcmaf, Bravo Yogurt™ Rerum® or other oral immune therapy treatments are complete as they help maintain daily gut and immune health, the intestinal macrophage pool  requires constant regeneration and does not self renew!

Clinical & Translational Immunology (2016)
Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel

Quark or quarg is a type of fresh dairy product made by warming soured milk until the desired amount of curdling is met, and then straining it. It can be classified as fresh acid-set cheese. Traditional quark can be made without rennet, but in modern dairies small quantities of rennet are typically added. It is soft, white and unaged, and usually has no salt added.

It is common in the cuisines of German speaking countries

Liquid whey strained from yogurt works fast, is bio concentrated with vitamins and minerals and has virtually no casein but still has plenty of lactose as an energy supply for probiotics. Since we have so much leftover sour whey after making home made kefir,  yogurt etc. (we use liquid whey to make bread and strained cream like cheese for desserts in addition to making our unstrained kefir and yogurt) I often just add it to my daily glass or two of whole fat milk so as not to waste it. It is great for weight loss, keeping blood sugar maintained and has all that milk does regarding immune factors in addition to amino acids and being a fabulous fast absorbed protein source, in fact the only protein source that that is not the same as animal or plant protein as it has far more benefits. Liquid whey is equal to milk for malnutrition and creates fast energy. I always dilute sour whey in milk because milk is AWESOME and a part of my daily nutrition and liquid whey just adds extra low calorie high nutritional, detox and immune value (acid whey is sour but less acidic than an apple). The intestinal macrophage pool requires daily replenishment in the form of yogurt, kefir, milk etc. Liquid whey added to milk will not create discomfort, bloating or gas after lactose tolerance is restored and is generally as well tolerated as yogurt and kefir even when added to milk. No need to fear dairy, it is necessary for health and is loaded with good things so get it however you can and start slow until tolerance is restored!

* Severe confirmed allergy or genetic intolerance to whey, lactose, casein or galactose not included (rare).

August 9, 2018

Diabetes Control And Dairy Sugars©

Patients with diabetes mellitus (DM) have infections more often than those without DM.

Disturbances in cellular innate immunity play a role in the pathogenesis of the increased prevalence of infections in DM patients. In general, a better regulation of the DM leads to an improvement of cellular function. A second important mechanism is the increased adherence of the microorganism to diabetic cells. This increased adherence to diabetic cells might also play a role for other microorganisms, for example the adherence of E. coli to uroepithelial cells, which would explain the increased prevalence of infections in patients with DM.

Mucosa-associated adherent, invasive Escherichia coli (E. coli), which are pro-inflammatory and resistant to killing by mucosal macrophages, may be associated with the pathogenesis of CD (Crohn’s Disease).

Concerning cellular innate immunity most studies show decreased functions (chemotaxis, phagocytosis, killing) of diabetic polymorphonuclear cells and diabetic monocytes/macrophages compared to cells of controls. In general, a better regulation of the diabetes leads to an improvement of these cellular functions.

Some microorganisms become more virulent in a high glucose environment.

Diabetic ketoacidosis, for example, is complicated by an infection in 75% of the cases. The mortality rate of patients with an infection and ketoacidosis is 43%.

An abnormal delayed type hypersensitivity reaction (DTH) (cell-mediated immunity) has also been described in DM type 1 and type 2 patients. Patients with DM do not generally have Pneumocystis carinii pneumonia or mycobacterial infections.

DTH is associated with syphilis and split immune tolerance.

Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to substances or tissue that have the capacity to elicit an immune response in given organism. It is induced by prior exposure to that specific antigen.

C. albicans infection is frequently found in diabetic patients. Risk factors for oral Candida carriage in patients with DM type 1 were a lower age and poor regulation of diabetes.

The lipid fraction of whey free fatty acids specifically inhibit the germination of Candida albicans, a morphologic change associated with pathogenicity.

It has been shown that severely ill diabetic patients have a decreased amount of galactose and sialic acid on their buccal cells, compared with minimally ill patients and healthy controls.

What is Galactose?

Galactose has been shown to be a very beneficial sugar that is actually an essential nutrient for the human body.

Milk sugar aka lactose has been shown to be very beneficial for the human body though. Unlike sucrose, lactose is made up of glucose and galactose. There is no fructose in lactose. It is a healthy disaccharide sugar.

Lactose does not cause intestinal necrosis (uncontrolled cell death) in premature infants.

β-galactosidase, also called lactase is important for organisms as a key provider in the production of energy and a source of carbons through the break down of lactose to galactose and glucose. It is also important for the lactose intolerant as many adult humans lack the lactase enzyme, which has the same function of beta-gal, so they are not able to properly digest dairy products.

Kefir grains show β-galactosidase enzyme activity, which stays active when consumed. β galactosidase enzymes found in kefir and yogurt are able to convert gc globulin protein to macrophage activating factors during the fermentation process. β-Galactosidase treatment is a common first-stage modification of the three major subtypes of Gc protein to GcMAF (a popular and effective immune therapy treatment).

Of the milk sugars, galactose, but not prebiotic galacto-oligosaccharide (GOS), improves insulin sensitivity.

Galactose at 15% of daily intake improved insulin sensitivity in rats compared to glucose and fructose. Galactose caused an increase in fed-state hepatic glycogen content and a favorable shift in gut microbial populations. Intake of galacto-oligosaccharides (GOS) improved the gut microbial profile but did not improve insulin sensitivity.

So in short galactose does both, improves hepatic function and leads to a favorable shift of microbe populations.

Lactose has no Fructose, instead it is made up of the essential sugar Galactose

Galactose contributes directly  to vital information and control processes in the body. It also functions as a fundamental and structural substance for cells, cell walls, and intracellular matrix.

Your Immune System Would Not Be Able To Function Without Galactose

Your body wouldn’t know which cells are “good” and what cells are “bad.” Your body wouldn’t know who the invaders were and which ones should be attacked by antibodies.

Galactose As New Immune Response Treatment Replacing IVIG

Galactose served as a second hook to attach sialic acid to antibodies in an experimental treatment for Lupus. Modification of this important process has led to breakthrough research for autoimmune syndromes like Lupus which may replace expensive and dangerous immune suppressing synthetic IVIG treatment. Data showed only antibodies involved in creating autoimmune disease or inflammation in the two models were affected by the treatment; the rest of the immune system continued to work as normal. Both kidney damage and joint inflammation were reduced.

Steroid, immune suppressing drugs and synthetic Vitamin D-induced down regulation of the cytokine response may not always be associated with optimal host defense. Effective clearance intra cellular organisms will depend on appropriate macrophage activation. The presence of 1,25-D3 disrupts this pathway, as IFN secretion is blocked, impairing macrophage activation.

Persistent blockade of these inhibitory receptors has lead to the breakdown in immune self tolerance, thereby increasing susceptibility to autoimmune or auto-inflammatory side effects, including rash, colitis, hepatitis and various endocrinopathies.

Galactose is known as the “brain sugar” and supports brain development of babies and children. Galactose helps triggers long-term memory formation. Galactose has been shown to inhibit tumor growth and stop its spread, particularly to the liver. This beneficial sugar can also enhance wound healing, decrease inflammation, enhances cellular communication, and increases calcium absorption.

The byproduct of cheese and yogurt production creates sweet and acid whey which historically was considered a waste product but today is considered a substantial bio functional food product. Sweet whey byproduct has been a food additive for years but today acid whey is being studied for its various health benefits as tons of acid whey are produced in the production of Greek Yogurt.

Acid whey contains more than twice the amount of galactose as ‘sweet’ or ‘cheese whey’ making it a beneficial addition to the control of insulin resistance, diabetes, metabolic syndrome and perhaps obesity.

Fast fact: Insulin resistance causes women to be unable to produce enough milk for breast feeding often leading to abandonment of this crucial practice and optimal immune start in life for their newborn.

 

August 7, 2018©

Dietary Whey Protein Lessens Many Risk Factors For Metabolic Diseases

Whey protein can be found in drinks, powder, protein bars, and milk.

Milk serum proteins are defined as substances that remain soluble in milk serum. These proteins are naturally formed during the production of cheese and account for 20% of the all protein in milk, such as β-lactoglobulins, α-lactalbumin, immunoglobulins, lactoferrin, lactoperoxidase, glycomacropeptide, bovine serum albumin, and other proteins.

Milk serum proteins do not coagulate in acidic conditions; they resist the action of quimosine from the stomach, quickly reach the jejunum, are rapidly digested, and raise plasma amino acid concentrations. Therefore, milk serum proteins perform several functions, such as mineral absorption, improvement of protein synthesis, sensitivity to hormones, and decreased blood glucose and lipid levels.

Amino acid, vitamin and mineral content become greatly concentrated in liquid whey making liquid whey, a bio super food equal to milk.

Whey protein may improve several risk factors for DM (diabetes mellitus) , obesity, hypertension, oxidative stress and MS (Metabolic Syndrome). In addition, new studies suggest a relationship between consumption of whey protein source foods and oxidative stress, hepatoprotective effects, and increased resting energy expenditure.

Component And Action Of Whey Protein On Immune Function

Immunoglobulin (10–15%)

Four classes of immunoglobulins are present in serum: IgG, IgA, IgM, and IgE. It functions as an antioxidant protection and increases immunity.

Only Whey Protein Or Diets That Contain This Protein Improve Antioxidant Function

Several studies also shown in different models of oxidative stress that only whey protein or diets that contain this protein improve antioxidant function and decrease oxidative stress as compared to consumption of other proteins.

Researchers observed a significant decrease in glucose, appetite, and food intake, and an increase in serum insulin levels after the consumption of a drink containing 50 g of whey protein when compared to the consumption of a similar amount of protein tuna, turkey, or egg albumin.

A major protein component of whey, α-lactalbumin has a higher content of tryptophan (6%) of all dietary proteins. It is rich in lysine, leucine, threonine, and cysteine. It has the ability to bind to minerals such as Ca and Zn, positively affecting their absorption.

Tryptophan, which is a precursor of serotonin is an important modulator of appetite.

Researchers also observed a significant hypoglycemic effect in individuals with insulin resistance after the consumption of a drink containing 30 g of whey protein plus 50 g of glucose compared to groups of individuals who consumed only 50 g glucose or another group who consumed 50 g of glucose plus 30 g of canola oil.

Diet is a major determinant of blood pressure. Likewise, certain foods have a direct role in the reduction of blood pressure or additional reductions in cardiovascular mortality. Some amino acids of the whey protein, e.g., α-lactalbumin and β-lactoglobulin, are precursors of peptide inhibitors of angiotensin-converting enzyme (ACE). ACE is a key enzyme in the regulation of blood pressure.

Whey  has an attractive effect on glucose metabolism control in healthy, overweight, obese, and insulin-resistant subjects. Whey protein assures a higher satiety; this effect is involved with the modulation of several gut hormones related to the reduction of food intake, with increased release of anorectic hormones, such as cholecystokinin, leptin, and GLP-1 and decreased release of the orexigenic hormone, ghrelin; and reduction of neuropeptide Y and increase of pro-opiomelanocortin in CNS. In addition, the reductions of expression of both inflammatory and oxidative stress markers, as well as the reduction in blood pressure, are also the main benefits of whey on risk factors for metabolic diseases.

Whey and casein proteins and medium-chain saturated fatty acids from milk do not increase low-grade inflammation in abdominally obese adults.

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Lactobacillus strains induced the expression of mu-opioid and cannabinoid receptors in intestinal epithelial cells and mediated analgesic functions in the gut-similar to the effects of morphine. Kefir contains many LAB species.

Tip:

Combine liquid whey collected from kefir with a glass of whole fat mammal milk. Liquid whey has the full complement of amino acids that are rapidly absorbed and proteins that are not destroyed as in powdered whey products. Start with one tbsp. liquid whey per day and work up to 1/4 cup. Liquid whey from homemade kefir is supercharged (alternavita exclusive recipe©) with many more beneficial organisms than simple collected whey from yogurt and will increase beneficial microbes not associated with obesity such as bifido. It is an excellent ‘whey’ to consume enough of the ‘correct protein’ daily requirement for anti oxidant protection without adding a lot of extra calories.

No other dietary protein including plant protein is equal to the health benefits found in mammal milk proteins.

Learn how to make kefir liquid whey here and here.

August 6, 2018©

Unproven Lyme Treatments Cause Serious Life-threatening Adverse Effects

Next to proton pump inhibitors or PPI’s (clinically shown to be worse for gut health than antibiotics), there is nothing you can do that is worse for gut and immune health than long term ineffective and unsafe drug therapy including anti virals, anti fungals, antibiotics, steroids and chemotherapeutics.

There is no such thing as a safe, synthetic pharmaceutical (or alcohol), ALL chronic drug use (including alcohol) highly contributes to liver failure, endocrine disorders, arthritis, inflammatory, autoimmune conditions, mental deterioration, AIDS, allergic conditions, chronic malnutrition syndromes, IBD, checkpoint blockade toxicity, endotoxemia, oxidative stress, cancer, overwhelming infection syndromes and early death.

Lyme disease Patients with persistent joint pain and other symptoms of are often offered unproven treatments that can cause serious and even life-threatening adverse effects.

Some patients who receive treatments for Lyme disease continue to experience symptoms such as pain, fatigue, and cognitive problems. This condition is sometimes described as chronic Lyme disease.

Clinicians who do diagnose chronic Lyme disease frequently treat patients with potentially dangerous therapies. The recommended treatment for Lyme disease is a course of antibiotics lasting two to four weeks, but some patients have been treated with antibiotics for months and even years. Long-term antibiotic therapy provides no benefit to patients with persistent Lyme symptoms and has led to severe bacterial infections and other complications.

Healthcare providers, including alternative medicine practitioners, have treated so-called chronic Lyme disease with many other unproven and risky therapies.

The elderly and those with immune deficiency syndromes are most susceptible to Lyme.

Mycoplasma, mold toxin illness, environmental toxin illness, and viral infections are all post immune deficiency and post immune suppression.

It is necessary to remember that the reactivity on ” the tests for HIV” – ELISA, Western blot, P 24 antigen, PCR or viral load – is caused by intoxication/oxidation.

For any infectious or parasitic disease to start, it is always a prerequisite that the host suffer IMMUNODEFICIENCY. At the same time, infectious and parasitic diseases themselves cause additional IMMUNE SUPPRESSION and more MALNUTRITION. This immune suppression is SECONDARY to the accumulation of free radicals, especially oxidizing species, that occurs during and after infectious and parasitic diseases.

Clinical Aspects of Immunology and Biochem J.

Happy Summer!

Alternavita – Right Track News

The higher protein concentration of infant formulas compared with breast milk has been suggested to be a source of metabolic stress on tissues such as the liver and kidneys in the still-developing infant. It is also thought to be a contributing factor to growth differences observed between formula-fed and breastfed infants. In a double-blind randomized controlled trial, 21 fed infants standard formula or α-lactalbumin–enriched formula (25% of total protein vs 11% in the standard formula) from 6 weeks to 6 months of age and compared them with breastfed infants. The protein content of each formula was 13.1 g/L. Compared with infants fed the standard formula, infants fed the α-lactalbumin–enriched formula had a growth pattern more similar to that of breastfed infants and plasma amino acid concentrations similar to or higher than those of breastfed infants.
Intestinal barrier loss alone is insufficient to initiate disease in IBD. A dysfunctional autophagic mechanism leads to chronic intestinal inflammation in IBD. The maintenance of gut mucosal equilibrium requires a balance between enterocyte loss by apoptosis and the generation of new cells by proliferation from stem cell precursors at the base of the intestinal crypts. Macrophages functions change during infection and inflammation. The intestinal macrophage pool requires continual renewal from circulating blood monocytes, unlike most other tissue macrophages, which derive from primitive precursors that subsequently self-renew.
SIBO can produce a mild to severe chronic encephalopathy. Gasotransmitters operate independently of immune receptors. Previously researchers have thought of signaling pathways as entailing a ligand binding to a receptor. However, gases can also trigger signaling cascades in the body. The best known is nitric oxide, or NO, which regulates a host of functions, notably blood pressure. H2S has a high co-morbidity with seizure activity.The liver has long been recognized as the primary organ of detoxification but, there is now growing evidence that the gut also plays a central role in the detoxification process. Given that the small intestine functions predominantly as an absorptive organ its significance in the metabolism of non-nutritive dietary constituents and xenobiotics seems to have been significantly underestimated. This is in spite of the fact that the small intestine is the first site of xenobiotic exposure and that, over the course of a lifetime, is presented with the largest load of antigens and xenobiotics confronting the human body.
Given that the small intestine functions predominantly as an absorptive organ its significance in the metabolism of non-nutritive dietary constituents and xenobiotics seems to have been significantly underestimated. Detoxification begins at the tips of the villi and the gut is equal to the liver for detoxification.
Macrophages functions change during infection and inflammation. The intestinal macrophage pool requires continual renewal from circulating blood monocytes, unlike most other tissue macrophages, which derive from primitive precursors that subsequently self-renew.
The vitamin D binding protein (DBP) was initially discovered as a major liver-derived polymorphic protein and called group-specific component or Gc. Vitamin D Binding Protein is otherwise know as: VDBP Gc-Protein Glycoprotein Transport protein Gc-Globulin. In general, total Gc-globulin levels are decreased in all patients with hepatotoxicity. Patients with ALF (Acute Liver Failure) have total Gc-globulin concentrations of approximately 100 mg/L which is less than one third of normal values.
Acute liver failure (fulminant hepatic failure) and prognosis. It is safe to say that acute liver failure (ALF) is one of the most dramatic conditions in medicine. The failing liver leads by definition to hepatic encephalopathy within a short time after initial symptoms and may also lead to a cascade of organ failures including renal failure, circulatory collapse, and pulmonary dysfunction. Further, severe infections, deep coagulopathy, and the risk of cerebral edema, intracranial hypertension, and cerebral herniation adds to the picture of an extreme disease entity. Not surprisingly, the mortality rate in ALF has historically been very high, with survival being the exception to the rule. So far, eleven clinical studies regarding Gc-globulin and ALF have been published. Eight studies have reported on total Gc-globulin levels. The results were very similar among the studies; Gc-globulin concentrations were reduced to between 25% and 49% of normal. Free Gc-globulin levels (reported in 5 studies) were even lower, between 12% and 26% of normal, and complex ratios (reported in 5 studies) were elevated in all papers. Thus, the stress on the actin scavenger system in ALF seems very obvious.

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